鲍泽华博士，浙江大学化工学院合成生物学研究中心“百人计划”研究员、博导，浙大杭州国际科创中心双聘学者。于伊利诺伊大学香槟分校Huimin Zhao课题组取得博士，后于波士顿大学生物设计中心Ahmad Khalil课题组接受博士后训练。迄今在Nat Biotechnol、ACS Synth Biol等专业期刊发表论文多篇，研究领域包括基因组工程、表观基因组工程、定向进化等。

2017 伊利诺伊大学香槟分校博士

2010 清华大学学士

2020至今浙江大学研究员

2018-2020 波士顿大学博士后

研究论文                 

1.   J. You, N. Singh, A. Reyes-Ordonez, N. Khanna, Z.Bao, H. Zhao, J. Chen (2020) ARHGEF3 regulates skeletal muscle regenerationand strength through autophagy. Cell Reports (Accepted)

2.   Z. Bao, M. HamediRad, P. Xue, H. Xiao, I. Tasan,R. Chao, J. Liang, H. Zhao (2018) Genome-scale engineering of Saccharomycescerevisiae with single nucleotide precision. NatureBiotechnology 36 (6), 505-508.

·   Highlighted by U.S. Department of Energy,AAAS, Illinois News Bureau, etc.

3.   J. Lian, Z. Bao, S. Hu, H. Zhao (2018)Engineered CRISPR/Cas9 system for multiplex genome engineering of polyploidindustrial yeast strains. Biotechnology and Bioengineering 115(6), 1630-1635.

4.   Z. Bao, S. Jain, V. Jaroenpuntaruk, H. Zhao(2017) Orthogonal genetic regulation in human cells using chemically inducedCRISPR/Cas9 activators. ACS Synthetic Biology 6 (4),686-693.

·   Recommended by F1000Prime

5.   Z. Jin, T. Schwend, J. Fu, Z. Bao, J.Liang, H. Zhao, W. Mei, J. Yang (2016) Members of the Rusc protein familyinteract with Sufu and inhibit vertebrate hedgehog signaling. Development 143(21), 3944-3955. 

·   Highlighted article: Regulating Hh signaling withRusc. Development 2016 143: e2014

6.   Z. Bao*, H. Xiao*, J. Liang, L. Zhang, X. Xiong,N. Sun, T. Si, H. Zhao (2014) Homology-Integrated CRISPR-Cas (HI-CRISPR) systemfor one-step multigene disruption in Saccharomyces cerevisiae. ACSSynthetic Biology 4 (5), 585-594.

·   ESI highly cited paper

7.   T. Si, Y. Luo, Z. Bao, H. Zhao (2014)RNAi-assisted genome evolution in Saccharomyces cerevisiae forcomplex phenotype engineering. ACS Synthetic Biology 4(3), 283-291.

8.   N. Sun, Z. Bao, X. Xiong, H. Zhao (2014)SunnyTALEN: a second-generation TALEN system for human genome editing. Biotechnologyand Bioengineering 111 (4), 683-691.

·   Selected as a spotlight article in BiotechnolBioeng, Vol. 111, No. 4, April, 2014

9.   J. Liang, R. Chao, Z. Abil, Z. Bao, H. Zhao(2014) FairyTALE: a high-throughput TAL effector synthesis platform. ACSSynthetic Biology 3 (2), 67-73.

·   Recommended by F1000Prime

·   Highlighted in ACS Synth. Biol. 2014,3, 52-53

10.  K. Yu, Z. Ming, Y. Li, C. Chen, Z. Bao, Z. Ren,B. Liu, W. Tao, Z. Rao, Z. Lou (2012) Purification, crystallization andpreliminary X-ray analysis of nonstructural protein 2 (nsp2) from avianinfectious bronchitis virus. Acta Crystallographica. Section F,Structural Biology and Crystallization Communications 68 (6),716-719.

11.  Y. Li, Z. Ren, Z. Bao, Z. Ming, X. Li (2011)Expression, crystallization and preliminary crystallographic study of theC-terminal half of nsp2 from SARS coronavirus. ActaCrystallographica. Section F, Structural Biology and CrystallizationCommunications 67 (7), 790-793.

综述文章

1.   Z. Bao*, R. E. Cobb*, H. Zhao (2016) Acceleratedgenome engineering through multiplexing. Wiley InterdisciplinaryReviews Systems Biology and Medicine 8 (1), 5-21.

·   Top ten accessed WSBM articles in 2016

2.   H. Xiao*, Z. Bao*, H. Zhao (2014) Highthroughput screening and selection methods for directed enzyme evolution. Industrial& Engineering Chemistry Research 54 (16), 4011-4020.