邵世群

浙江大学百人计划研究员、博士生导师、国家海外青年人才项目入选者

浙江大学化学工程与生物工程学院，浙江省杭州市，310058

电话：0571-87072798；E-mai1：shiqun.shao@zju.edu.cn

教育与工作经历

2006-2010，学士，浙江大学化学工程与生物工程学院，导师：申有青教授

2010-2016，工学博士，浙江大学化学工程与生物工程学院，导师：申有青教授

2016-2018，博士后，美国加州大学河滨分校，合作导师：Min Xue教授

2018-2020，博士后，美国系统生物学研究所，合作导师:Wei Wei教授

2021-至今，百人计划研究员，浙江大学化学工程与生物工程学院

研究领域

高分子的靶向蛋白调控与分析方法研究，具体包括：1）蛋白稳态调控；2）蛋白靶向递送；3）蛋白信号动态分析

奖励和荣誉等

国家海外青年人才入选者（2022）

国家自然科学奖二等奖（5/5，2023）

浙江省自然科学一等奖（4/5，2021）

中国发明协会发明创业奖创新奖一等奖（4/6，2023）

ISB Innovator Award（1/3，2019）

代表性论文

[23] Yunzhou Guo, Yang Han, Yangyang Cao, Yuping Chen, Jingwen Xie, Hanchen Ding, Shifu Liang, Xin Liu*, Wenjing Sun, Jianbin Tang, Shiqun Shao*, Jiajia Xiang*, Youqing Shen, Facile Fabrication of Tough Super Macroporous Hydrogel via Enhanced Phase Separation. Advanced Functional Materials, 2024, 2412412.

[22] Shasha Yao#, Yi Wang#, Qian Tang#, Yujie Yin, Yu Geng, Lei Xu, Shifu Liang, Jiajia Xiang*, Jiaqi Fan, Jianbin Tang, Jian Liu*, Shiqun Shao*, Youqing Shen, A plug-and-play monofunctional platform for targeted degradation of extracellular proteins and vesicles, Nature Communications, 2024, 15(1):7237.

[21] Ying Piao, Sebastian Himbert, Zhihao Zhao, Zifan Li, Huahai Yu, Shiqun Shao*, Shuangshuang Liu, Jun Liu, Michael Fefer, Maikel Rheinstadter*, Youqing Shen*, Alkylated EDTA Potentiates Antibacterial Photodynamic Activity of Protoporphyrin, Journal of Nanobiotechnology, 2024, 22(1):161.

[20] Quan Zhou#, Jiajia Xiang#, Nasha Qiu, Yechun Wang, Ying Piao, Shiqun Shao*, Zhuxian Zhou*, Jianbin Tang, Youqing Shen*, Tumor Abnormality-oriented Nanomedicine Design, Chemical Reviews, 2023, 123, 10920-10989.

[19] Runnan Zhang#, Shiqun Shao#, Ying Piao, Jiajia Xiang, Xuyong Wei, Zhen Zhang, Zhuxian Zhou, Jianbin Tang, Nasha Qiu*, Xiao Xu*, Yanpeng Liu*, Youqing Shen*, Esterase-Labile Quaternium Lipidoid Enabling Improved mRNA-LNP Stability and Spleen-Selective mRNA Transfection, Advanced Materials, 2023, 35, 2303614.

[18] Jiajia Xiang#, Jing Liu#, Xin Liu, Quan Zhou, Zhihao Zhao, Shiqun Shao*, Zhuxian Zhou, Jianbin Tang, Youqing Shen*, Enzymatic Drug Release Cascade from Polymeric Prodrug Nanoassemblies Enables Targeted Chemotherapy, Journal of Controlled Release, 2022, 348, 444-455.

[17] Wufa Fan, Qiuyu Wei, Yisi Tang, Jiajia Xiang, Quan Zhou, Yu Geng, Yanpeng Liu, Rui Sun, Lei Xu, Guowei Wang, Ying Piao, Shiqun Shao*, Zhuxian Zhou, Jianbin Tang, Zichen Li*, Youqing Shen*, Mucus penetrating and cell-binding polyzwitterionic micelles as potent oral nanomedicine for cancer drug delivery, Advanced Materials, 2022, 34, 2109189.

[16] Jiajia Xiang#, Yihuai Shen#, Yifan Zhang#, Quan Zhou, Jianbin Tang, Shiqun Shao*, Youqing Shen*, Multipotent poly(tertiary amine-oxide) micelles for efficient cancer drug delivery, Advanced Science, 2022, 9, 2200173.

[15] Yu Geng, Jiajia Xiang, Shiqun Shao*, Jianbin Tang, Youqing Shen*, Mitochondria-targeted polymer-celastrol conjugate with enhanced anticancer efficacy, Journal of Controlled Release, 2022, 342, 122-133. (Featured as Outside Back Cover)

[14] Shiqun Shao#, Quan Zhou#, Jingxing Si, Jianbin Tang, Xiangrui Liu, Meng Wang, Jianqing Gao, Kai Wang, Rongzhen Xu, Youqing Shen*, A Non-cytotoxic Dendrimer with Innate and Potent Anticancer and Anti-metastatic Activities. Nature Biomedical Engineering, 2017, 1, 745–757.

[13] Shiqun Shao, Zhonghan Li, Hanjun Cheng, Siwen Wang, Nicole Perkins, Priyanka Sarkar, Wei Wei, Min Xue*, A Chemical Approach for Profiling Intracellular AKT Signaling Dynamics from Single Cells. Journal of the American Chemical Society, 2018, 140, 13586-13589.

[12] Quan Zhou#, Shiqun Shao#, Jinqiang Wang, Changhuo Xu, Jiajia Xiang, Ying Piao, Qingsong Yu, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Zhihua Gan, Zhen Gu*, Youqing Shen*, Enzyme-activatable Polymer–Drug Conjugate Augments Tumour Penetration and Treatment Efficacy. Nature Nanotechnology, 2019, 14, 799-809.

[11] Jingxing Si#, Shiqun Shao#, Youqing Shen*, Kai Wang*, Macrophages as Active Nanocarriers for Targeted Early and Adjuvant Cancer Chemotherapy. Small, 2016, 12, 5108–5119.

[10] Shiqun Shao#, Jingxing Si#, Jianbin Tang, Meihua Sui*, Youqing Shen*, Jellyfish-Shaped Amphiphilic Dendrimers: Synthesis and Formation of Extremely Uniform Aggregates. Macromolecules, 2014, 47, 916–921.

[9] Shiqun Shao, Youqing Shen*, Copper-enhanced Cytotoxicity of PEG-PDTC Nanomedicines. Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12, 470-471.

[8] Shiqun Shao, Min Xue*, Supramolecular Analytical Chemistry in Cancer Research. Advances in Cancer Research, 2018, 139, 147-161.

[7] Shiqun Shao#, Jingxing Si#, Youqing Shen*, Copper as the Target for Anticancer Nanomedicine. Advanced Therapeutics, 2019, 2, 1800147.

[6] Fei Ji#, Shiqun Shao#, Zhonghan Li, Siwen Wang, Rohit Chaudhuri, Zhili Guo, Nicole Perkins, Priyanka Sarkar, Min Xue*, A Cyclic Peptide Antenna Ligand for Enhancing Terbium Luminescence. Analyst, 2021, 146, 3474-3481. (Inside Back Cover)

[5] Fei Ji, Siwen Wang, Shiqun Shao, Priyanka Sarkar, Min Xue*,Real-time analysis of AKT signaling activities at single-cell resolution using cyclic peptide-based probes, Methods in Molecular Biology, 2022, 2394:65-80.

[4] Hanjun Cheng#, Zhonghan Li#, Zhili Guo, Shiqun Shao, Li Mo, Wei Wei*, Min Xue*, Single-cell profiling of D-2-hydroxyglutarate using surface-immobilized resazurin analogs. Biosensors and Bioelectronics, 2021, 15:190:113368.

[3] Priyanka Sarkar, Zhonghan Li, Wendan Ren, Siwen Wang, Shiqun Shao, Jianan Sun, Xiaodong Ren, Nicole G. Perkins, Zhili Guo, Chia-En A. Chang, Jikui Song, Min Xue*, Inhibiting Matrix Metalloproteinase-2 Activation by Perturbing Protein–Protein Interactions Using a Cyclic Peptide. Journal of Medicinal Chemistry, 2020, 63, 6979-6990.

[2] Zhonghan Li, Shiqun Shao, Xiaodong Ren, Jianan Sun, Zhili Guo, Siwen Wang, Chia-en Chang, Min Xue*, Construction of A Sequenceable Protein Mimetic Peptide Library with A Real 3D Diversifiable Chemical Space. Journal of the American Chemical Society, 2018, 140, 14552-14556.

[1] Zhonghan Li#, Hanjun Cheng#, Shiqun Shao, Xiang Lu, Li Mo, Jonathan Tsang, Pu Zeng, Zhili Guo, Siwen Wang, David A. Nathanson, James R. Heath, Wei Wei*, Min Xue*, Surface Immobilization of Redox-labile Fluorescent Probes: Enabling Single-cell Co-profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities. Angewandte Chemie International Edition, 2018, 130, 11728-11732.