相佳佳，博士，浙江大学百人计划研究员，博士生导师。2012年获浙江大学高分子材料与工程专业学士学位；2018年获浙江大学生物化工专业博士学位，师从申有青教授；2019年获浙江大学-斯坦福联合博士后项目资助从事博士后研究，2021年9月入职浙江大学杭州国际科创中心，任科创百人研究员；2023年6月起加入浙江大学化学工程与生物工程学院生物工程研究所，任百人计划研究员。现担任中国抗癌协会纳米肿瘤学专业委员会青年委员、Frontiers in Materials客座编辑。
主要从事生物医用高分子材料、靶向药物递送等方面的研究。以第一/通讯作者在Chem. Rev.、Nat. Biomed. Eng.、Nat. Commun.、Adv. Mater.、Adv. Funct. Mater.、Adv. Sci.、ACS Nano、Nano Lett.、J. Control. Release等期刊发表论文30余篇，授权中国发明专利9项，美国专利2项。
浙江大学化学工程与生物工程学院，浙江省杭州市，310058
电话：0571-87952798 E-mail: xiang_jj@zju.edu.cn
一、接受高等教育情况
学校/单位名称 | 学习时间(自/至) | 主修专业/内容 | 所获学位 |
浙江大学 | 2008.09-2012.06 | 高分子材料与工程专业 | 学士学位 |
浙江大学 | 2012.09-2018.06 | 生物化工专业 导师：申有青 | 博士学位 |
二、工作经历
工作单位 | 工作时间(自/至) | 专业技术职务/行政职务 |
浙江大学 | 2019.06-2021.08 | 浙江大学-斯坦福联合博士后 |
浙江大学杭州国际科创中心 | 2021.09-2023.05 | 百人计划研究员 |
浙江大学 | 2023.06-至今 | 百人计划研究员 |
三、荣誉奖励
2023 中国发明协会发明创新奖一等奖（5/6）
2023 海南省专利优秀奖（4/4）
四、发表论文
（#为共同一作，*为通讯作者）
1. Yunzhou Guo, Yang Han, Yangyang Cao, Yuping Chen, Jingwen Xie, Hanchen Ding, Shifu Liang, Xin Liu*, Wenjing Sun, Jianbin Tang, Shiqun Shao*, Jiajia Xiang*, Youqing Shen, Facile fabrication of tough super macroporous hydrogel via enhanced phase separation, Advanced Functional Materials 2024, 2412412.
2. Yufei Zheng#, Zhaowei Zhang#, Zezhou Fu#, Aimi Fan, Nan Song, Qingqing Wang, Shunwu Fan, Jianbin Xu*, Jiajia Xiang*, and Xin Liu*, Oral propolis nanoemulsions modulate gut microbiota to balance bone remodeling for enhanced osteoporosis therapy, ACS Nano 2024, 18(38), 26153-26167.
3. Shasha Yao#, Yi Wang#, Qian Tang#, Yujie Yin, Yu Geng, Lei Xu, Shifu Liang, Jiajia Xiang*, Jiaqi Fan, Jianbin Tang, Jian Liu*, Shiqun Shao* and Youqing Shen, A plug-and-play monofunctional platform for targeted degradation of extracellular proteins and vesicles, Nature Communications 2024, 15, 7237.
4. Guiping Yuan#, Minghui Li#, Yifan Zhang, Qiuyang Dong, Shiqun Shao, Zhuxian Zhou, Jianbin Tang, Jiajia Xiang*, Youqing Shen*, Modulating intracellular dynamics for optimized intracellular release and transcytosis equilibrium, Advanced Materials 2024, 2400425
5. Xin Liu#, Yufei Zheng#, Qingqing Wang#, Lan Zhao, Zhaowei Zhao, Haoli Wang, Nan Song, Jiajia Xiang*, Youqing Shen*, Shunwu Fan*, Artificially reprogrammed stem cells deliver transcytosable nanocomplexes for improved spinal cord repair, Journal of Controlled Release, 2023, 64, 601–617.
6. Quan Zhou#, Jiajia Xiang#, Nasha Qiu, Yechun Wang, Ying Piao, Shiqun Shao*, Jianbin Tang, Zhuxian Zhou*, and Youqing Shen*, Tumor abnormality-oriented nanomedicine design, Chemical Reviews, 2023, 123, 10920−10989.
7. Guiping Yuana#, Yifan Zhang#, Shiqun Shao, Zhuxian Zhou, Jianbin Tang, Jiajia Xiang*, Youqing Shen*, Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy, Journal of Controlled Release 2023, 361, 792-802.
8. Jiajia Xiang#, Kexin Liu#, Hongxia Xu, Zhihao Zhao, Ying Piao, Shiqun Shao, Jianbin Tang, Youqing Shen, Zhuxian Zhou*, Dual synergistic tumor-specific polymeric nanoparticles for efficient chemo-immunotherapy, Advanced Science, 2023, 2301216.
9. Wufa Fan#, Jiajia Xiang#, Qiuyu Wei#, Yisi Tang#, Ying Piao, Shiqun Shao, Zhuxian Zhou, Jianbin Tang, Zichen Li, Youqing Shen*, Role of micelle size in cell transcytosis-based tumor extravasation, infiltration, and treatment efficacy, Nano Letters, 2023, 23(9), 3904-3912.
10. Xiaoyu Ding#, Xiaowen Xing#, Jianfeng Liu#, Pengchong Zhu, Cui Wang, Rui Bai, Bo Kong,Chuyang Zeng, Wei Zhang, Yin Yue, Jiajia Xiang*, Zengqiang Yuan*, Zhiqiang Liu*, Cobweb-inspired microenvironment-targeting nanosystem with sequential multiple-stage stimulus-response capacity for ischaemic tissue repair, Advanced Functional Materials 2023, 2301451.
11. Jiajia Xiang, Shiqun Shao, Zhuxian Zhou*, and Youqing Shen*, “One-for-all” approach: A black technology for nanomedicine development? Medical Review 2023, 3(2), 184-187.
12. Zhihao Zhao#, Yupu Feng#, Jiajia Xiang#, Jing Liu, Ying Piao, Shiqun Shao, Zhuxian Zhou, Jianbin Tang, Youqing Shen*, Screening of zwitterionic liposomes with red blood cell-hitchhiking and tumor cell-active transporting capability for efficient tumor entrance, Advanced Functional Materials, 2023, 33(16), 2214369.
13. Rui Sun#, Jiajia Xiang#, Quan Zhou#, Ying Piao, Jianbin Tang, Shiqun Shao, Zhuxian Zhou*, You Han Bae*, and Youqing Shen*, The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives, Advanced Drug Delivery Reviews, 2022, 191, 114614.
14. Jiajia Xiang#, Yifan Zhang#, Xin Liu, Quan Zhou, Ying Piao, Shiqun Shao, Jianbin Tang, Zhuxian Zhou*, Tao Xie, and Youqing Shen*, Natural polyphenols-platinum nanocomplexes stimulate immune system for combination cancer therapy, Nano Letters 2022, 22, 5615−5625.
15. Sunbin Ling#, Qifan Zhan#, Guangjiang Jiang#, Qiaonan Shan, Lu Yin, Rui Wang, Qingyang Que, Xuyong Wei, Shengjun Xu, Jiongjie Yu, Wei Zhou, Lincheng Zhang, Jiaqi Bao, Qianwei Ye, Renyi Su, Rongli Wei, Jimin Liu, Kangchen Chen, Jingrui Wang, Haiyang Xie, Shusen Zheng, Xin He, Jiajia Xiang*, Xiao Xu*, E2F7 promotes mTOR inhibitor resistance in hepatocellular carcinoma after liver transplantation. American Journal of Transplantation 2022, 22(10), 2323-2336.
16. Jiajia Xiang#, Jing Liu#, Xin Liu, Quan Zhou, Zhihao Zhao, Ying Piao, Shiqun Shao*, Zhuxian Zhoua, Jianbin Tang, Youqing Shena*, Enzymatic drug release cascade from polymeric prodrug nanoassemblies enables targeted chemotherapy. Journal of Controlled Release 2022, 348, 444-455.
17. Doudou Hu, Wei Zhang, Jiajia Xiang*, Dongdong Li, Yong Chen, Pengcheng Yuan, Shiqun Shao, Zhuxian Zhou, Youqing Shen, Jianbin Tang*, A ROS-responsive synergistic delivery system for combined immunotherapy and chemotherapy. Materials Today Bio 2022, 14, 100284.
18. Jiajia Xiang#, Yihuai Shen#, Yifan Zhang#, Xin Liu, Quan Zhou, Zhuxian Zhou, Jianbin Tang, Shiqun Shao*, Youqing Shen*, Multipotent poly(tertiary amine-oxide) micelles for efficient cancer drug delivery. Advanced Science 2022, 9(12), 2200173.
19. Jiajia Xiang#, Xin Liu#, Guiping Yuan, Runnan Zhang, Quan Zhou, Tao Xie, Youqing Shen*, Nanomedicine from amphiphilized prodrugs: Concept and clinical translation. Advanced Drug Delivery Reviews 2021, 179, 114027.
20. Kexin Liu#, Jiajia Xiang#, Guowei Wang, Hongxia Xu, Xiangrui, Liu, Jianbin Tang, Youqing Shen, Zhuxian Zhou*, Linear-dendritic polymer-platinum complexes forming well-defined nanocapsules for acid-responsive drug delivery. ACS Applied Materials & Interfaces 2021, 13, 44028-44040.
21. Jiajia Xiang#, Peiwen Xing#, Liu Xin, Peihong Shen, Shiqun Shao, Quan Zhou, Zhuxian Zhoua, Jianbin Tang, Youqing Shen*, Hydrogen sulfide-activatable prodrug-backboned block copolymer micelles for delivery of chemotherapeutics. Polymer Chemistry 2021, 12, 4167-4174.
22. Quan Zhou#, Jiajia Xiang#, Lingqiao Hao, Xiaojie Xu, Zhuxian Zhou, Jianbin Tang, Yuan Ping, Youqing Shen*, Polyplex nanovesicles of single strand oligonucleotides for efficient cytosolic delivery of biomacromolecules. Nano Today 2021, 39, 101221.
23. Siqin Chen#, Yin Zhong#, Wufa Fan#, Jiajia Xiang#, Guowei Wang, Quan Zhou, Jinqiang Wang, Yu Geng, Rui Sun, Zhen Zhang, Ying Piao, Jianguo Wang, Jianyong Zhuo, Hailin Cong, Haiping Jiang, Jun Ling, Zichen Li, Dingding Yang, Xin Yao, Xiao Xu, Zhuxian Zhou, Jianbin Tang, and Youqing Shen*. Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity. Nature Biomedical Engineering 2021, 5, 1019-1037.
24. Shengjun Xu, Sunbin Ling, Qiaonan Shan, Qianwei Ye, Qifan Zhan, Guangjiang Jiang, Jianyong Zhuo, Binhua Pan, Xue Wen, Tingting Feng, Haohao Lu, Xuyong Wei, Haiyang Xie, Shusen Zheng, Jiajia Xiang*, Youqing Shen, and Xiao Xu*. Self-activated cascade-responsive sorafenib and USP22 shRNA co-delivery system for synergetic hepatocellular carcinoma therapy. Advanced Science 2021, 8(5), 2003042.
25. Jiajia Xiang, Yinwen Li*, Yifan Zhang, Guowei Wang, Hongxia Xu, Zhuxian Zhou, Jianbin Tang, and Youqing Shen*. Polyphenol-cisplatin complexation forming core-shell nanoparticles with improved tumor accumulation and dual-responsive drug release for enhanced cancer chemotherapy. Journal of Controlled Release 2021, 330, 992-1003.
26. Chengyuan Dong#, Quan Zhou#, Jiajia Xiang*, Fusheng Liu*, Zhuxian Zhou*, Youqing Shen. Self-assembly of oxidation-responsive polyethylene glycol-paclitaxel prodrug for cancer chemotherapy. Journal of Controlled Release 2020, 321, 529-539.
27. Xinchi Jiang#, Jiajia Xiang#, Honghui Wu, Tianyuan Zhang, Danping Zhang, Qianhao Xu, Xiaoli Huang, Xianglei Kong, Jihong Sun, Yulan Hu, Kai Li, Yasuhiko Tabata, Youqing Shen*, and Jianqing Gao*. Neural stem cells transfected with reactive oxygen species–responsive polyplexes for effective treatment of ischemic stroke. Advanced Materials 2019, 31, 1807591.
28. Jiajia Xiang#, Xin Liu#, Zhuxian Zhou, Dingcheng Zhu, Quan Zhou, Ying Piao, Liming Jiang, Jianbin Tang, Xiangrui Liu, and Youqing Shen*. Reactive oxygen species (ROS)-responsive charge-switchable nanocarriers for gene therapy of metastatic cancer. ACS Applied Materials & Interfaces 2018, 10, 43352-43362.
29. Jiajia Xiang#, Bihan Wu#, Zhuxian Zhou, Shiqi Hu, Quan Zhou, Guowei Wang, Jianbin Tang, Xiangrui Liu, and Youqing Shen*. Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy. Science China Life Sciences 2018, 61, 436–447.
30. Xin Liu#, Jiajia Xiang#, Dingcheng Zhu, Liming Jiang, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Yongzhuo Huang, and Youqing Shen*. Fusogenic reactive oxygen species triggered charge-reversal vector for effective gene delivery. Advanced Materials 2016, 28, 1743-1752.
五、工作研究项目
1. 国家自然科学基金青年科学基金项目，主动渗透型药物输送系统的构建与胰腺癌免疫治疗的研究(52203193)，主持，2023 - 2025。
2. 中国博士后科学基金面上资助(第66批)，环境响应型纳米药物协同输送体系的制备及其生物应用(2019M662046)，主持，2019 - 2021。
六、专利成果
1. 申有青，周泉，徐昌活，相佳佳，一种γ-谷氨酰转肽酶催化水解致电荷反转的聚合物及其在药物输送领域的应用，中国专利（ZL201710917814.5），已授权，2021-02-26。
2. 申有青，吴碧寒，相佳佳，朴莹，一种聚乙二醇-聚赖氨酸/异硫氰酸酯键合物及其作为药物载体的应用，中国专利（ZL201810045332.X），已授权，2020-05-29。
3. 徐骁，申有青，相佳佳，许圣均，凌孙彬，单巧南，一种用于癌症治疗的索拉非尼-基因共载纳米药物及其制备方法和应用，中国专利（ZL202010992093.6），已授权，2021-08-17。
4. 周珠贤，刘珂鑫，相佳佳，唐建斌，刘祥瑞，申有青，聚乙二醇-树枝状聚赖氨酸/酸酐-顺铂复合物及其制备方法和应用，中国专利（ZL202010413826.6），已授权，2021-11-09。
5. 徐骁，相佳佳，陶耀业，王建国，申有青，柯庆宏，岑贝妮，一种氧化响应去电荷的阳离子聚合物及其制备方法和应用，中国专利（ZL202011450807.7），已授权，2021-10-15。
6. 徐骁，王建国，陶耀业，相佳佳，柯庆宏，申有青，一种缺氧响应的阳离子聚合物及其制备方法和应用，中国专利（ZL202011302610.9），已授权，2021-10-15。
7. 申有青，刘衍朋，相佳佳，罗珂筠，孙瑞，周珠贤，一种氟化端基两亲性聚合物、其制备方法及应用，中国专利（ZL202111533789.3），已授权，2023-09-01。
8. 相佳佳，曹杨羊，陈玉平，邵世群，一种用于检测铜离子的荧光探针及其制备方法与应用，中国专利（ZL202310024747.X），已授权，2024-04-05。
9. 相佳佳，郭云舟，陈玉平，韩阳，邵世群，一种超大孔水凝胶及其制备方法和应用，中国专利（ZL202310030838.4），已授权，2024-11-08。
10. Youqing Shen, Quan Zhou, Changhuo Xu, Jiajia Xiang, Polymer of gamma-glutamyl transpeptidase catalyzing hydrolysis-induced charge reversal and its application in the field of drug delivery, PCT/CN2018/106827, US patent (US11364232B2), granted (2022-06-21).
