周珠贤

周珠贤，浙江大学求是特聘教授

国家杰青（2024年），教育部青年长江学者（2020年），Chemical Engineering Journal期刊编辑（新材料与生物技术方向），化学反应工程与工艺期刊编辑。1999-2006期间在浙江大学高分子科学与工程学系攻读本科、硕士学位，2006-2011期间在美国University of Wyoming攻读化学工程博士学位，2011-2015期间在美国Case Western Reserve University生物医学工程系从事博士后研究，于2015年回国加入浙江大学化学工程与生物工程学院。主要从事功能高分子载体材料应用于药物分子、生物大分子和影像分子等功能分子高效递送的基础及临床转化研究。已发表SCI收录论文130余篇，包括Nat. Nanotech., Nat. Biomed. Eng., Nat. Commun., Angew.Chem., Adv. Mater., Adv. Funct. Mater., Biomaterials, Adv. Drug Deliv. Rev.等国际著名期刊，论文引用超1万次，H因子为47，授权中国发明专利20余项，作为主要成员参与多项创新纳米药物的临床转化工作。主持国家杰出青年科学基金1项，面上、青年项目4项，参与科技部、基金委重大、重点等项目3项。获国家自然科学二等奖（2023，3/5），浙江省自然科学一等奖（2021，3/5），发明家协会发明创业奖创新奖一等奖（2023，2/6），生物材料学会生物医用高分子材料优秀青年学者奖（2023），全国“互联网+”大学生创新创业大赛金奖团队指导老师（2024），浙江大学优秀德育导师（2024），浙江大学优秀班主任（2017），浙江大学先进工作者（2016）等奖励和荣誉称号。

1. 接受高等教育情况

2．工作经历

自2015年3月进入浙江大学生物工程与化学工程学院工作，所在一级学科为化学工程与技术

教学工作：

（1）讲授本科生课程《生物纳米技术概论》（2017年-至今）、《认识实习》（2015年-2018年）、《生产实习》（2015年-至今）；合作讲授本科生课程《蛋白质工程》（2017年-2018年）和研究生课程《纳米生物技术》（2016年-至今）、《生物化工前沿》（2020年-至今）、《现代制药技术》（2021年-至今）；

（2）每年指导本科生毕业论文1-3名，每年指导本科生SRTP科研训练1-3名；

（3）担任生工所本科生班主任（2016-2019年），生工所研究生德育导师（2019年至今，主管评奖评优与日常）；

科研工作经历

硕士研究生期间在浙江大学高分子系沈之荃先生领导的稀土组，从事新型含联噻唑环聚合物及其金属配合物的设计, 制备和性能研究，导师是孙维林教授。2006年2月出国，博士研究生期间在美国怀俄明大学化学工程与石油工程系，从事功能高分子应用于靶向药物递送的研究，导师是申有青教授。博士后期间在美国凯斯西储大学生物医学工程系，从事肿瘤靶向核磁共振纳米探针的设计及应用于肿瘤早期检测与精准诊断的研究，合作导师是Zheng-Rong Lu教授。2015年2月回国，加入浙江大学化学工程与生物工程学院生物工程研究所，从事生物医用高分子材料的设计及其应用于药物递送、疾病诊断与治疗的基础与临床转化研究。

研究方向

智能生物医用高分子材料应用于影像分子、药物分子与生物大分子等功能分子的疾病靶向递送与高效治疗，

（1）智能生物医用高分子载体材料的精准合成与修饰；

（2）智能生物医用高分子载体材料用于疾病的早期检测、精准诊断与手术导航；

（3）智能生物医用高分子载体材料用于疾病的高效靶向治疗。

3．在研项目

（1）国家自然科学基金-国家杰出青年科学基金，高分子药物载体材料，主持，400万，2025年1月-2029年12月。

（2）国家自然科学基金-面上项目，高通量筛选荧光树状大分子载体介导蛋白质药物肿瘤主动运输的研究，主持，65万，2024年1月-2027年12月。

（3）国家自然科学基金-面上项目，主动运输型高分子载体的设计及应用于肿瘤的高效治疗，主持，70.8万，2021年1月-2024年12月。

（4）国家自然科学基金-面上项目，内部串级修饰功能集合型树状大分子的构建及其应用于抗癌药物输送，主持，78万，2019年1月-2022年12月。

（5）国家自然科学基金-青年科学基金项目，肿瘤微环境靶向和响应性的高分子-顺铂纳米囊泡作为抗癌药物的研究，主持，25万，2017年1月-2019年12月。

（6）国家自然科学基金-广东联合基金-重点支持项目，作用于肿瘤微环境的非细胞毒化物型高效抗肿瘤高分子的设计，参与，120 万，2016年1月-2019年12月。

（7）国家重点研发计划-纳米前沿，肿瘤主动渗透型智能纳米药物的创制与临床转化，课题一.肿瘤响应转胞运载体的设计、合成与纳米药物可控构筑，参与，432 万，2021年12月-2026年12月。

（8）浙江省重点研发项目，满足精准医疗需求的关键材料研发-高效抗肿瘤纳米药物的创制与临床转化，参与，260万，2020年1月-2024年1月。

4. 招生情况

（1）导师资格

博士生导师、硕士生导师： (0817) 化学工程与技术（学术学位） 、(0860) 生物与医药（专业学位）、(0856) 材料与化工（专业学位）

（2）招生名额

按照学院规定国家级高层次人才每年可招博士研究生3人、硕士研究生3人。

欢迎有志于科研、对生物医用高分子材料与药物递送领域感兴趣的同学报考，招收生物工程、高分子、化学、药剂学、化工、细胞/生物学、医学等专业背景学生。

5. 论文发表

1．Wang, Guowei; Zhang, Chengyue; Huang, Zixuan; Chen, Jifan; Chen, Hongjian; Lin, Tao; Zhou, Zhuxian*; Gu, Ning*; Huang, Pintong*. Transcytosable and Ultrasound-Activated Liposome Enables Deep Penetration of Biofilm for Surgical Site Infection Management. Advanced Materials, 2024: e2411092.

2．Liu, Jiwei; Xiao, Bing; Yang, Yongle; Jiang, Yifan; Wang, Rui; Wei, Qi; Pan, Yixuan; Chen, Yuping; Wang, Huimin; Fan, Jiaqi; Li, Ruoshui; Xu, Haoran; Piao, Ying; Xiang, Jiajia; Shao, Shiqun; Zhou, Zhuxian; Shen, Youqing; Sun, Wenjing*; Tang, Jianbin*. Low-Dose Mildronate-Derived Lipidoids for Efficient mRNA Vaccine Delivery with Minimal Inflammation Side Effects. ACS Nano, 2024, 18(34): 23289-23300.

3．Yuan, Guiping; Li, Minghui; Zhang, Yifan; Dong, Qiuyang; Shao, Shiqun; Zhou, Zhuxian; Tang, Jianbin; Xiang, Jiajia*; Shen, Youqing*. Modulating Intracellular Dynamics for Optimized Intracellular Release and Transcytosis Equilibrium. Advanced Materials, 36(25): e2400425.

4．Wang, Zhehao; Sun, Yuji; Shen, Youqing; Zhou, Zhuxian*. Stimuli-Responsive Nanocarriers for Transcytosis-Based Cancer Drug Delivery. Advanced Nanobiomed Research, 2024, 4: e2300125.

5．Wan, Qianyu; Sun, Yuji; Sun, Xuanrong*; Zhou, Zhuxian*. Rational design of polymer-based mRNA delivery systems for cancer treatment. Polymer Chemistry, 2024, 15, 2437-2456.

6．Hu, Qiuhui; Su, Yongzhao; Ma, Siying; Wei, Peiying; He, Chengbin; Yang, Di; Qian, Yue; Shen, Youqing; Zhou, Xiaoxuan*; Zhou, Zhuxian*; Hu, Hongjie*. Integrin-Targeted Theranostic Nanoparticles for Clinical MRI-Traceable Treatment of Liver Fibrosis. 2024, 16(2): 2012-2026.

7．Qin, Yating; Wang, Guowei; Chen, Linying; Sun, Yuji; Yang, Jiajia; Piao, Ying; Shen, Youqing; Zhou, Zhuxian*. High-Throughput Screening of Surface Engineered Cyanine Nanodots for Active Transport of Therapeutic Antibodies into Solid Tumor. Advanced Materials, 2024, 36(9): e2302292.

8．Yu, Huahai; Piao, Ying; Zhang, Yifan; Xiang, Jiajia; Shao, Shiqun; Tang, Jianbin; Zhou, Zhuxian*; Shen, Youqing*. Cell-Selective Binding Zwitterionic Polymeric Micelles Boost the Delivery Efficiency of Antibiotics. ACS Nano 2023, 17(22): 22430-22443.

9．Zhang, Runnan; Shao, Shiqun; Piao, Ying; Xiang, Jiajia; Wei, Xuyong; Zhang, Zhen; Zhou, Zhuxian; Tang, Jianbin; Qiu, Nasha*; Xu, Xiao*; Liu, Yanpeng*; Shen, Youqing*. Esterase-Labile Quaternium Lipidoid Enabling Improved mRNA-LNP Stability and Spleen-Selective mRNA Transfection. Advanced Materials, 2023, 35(46):e2303614.

10．Shi, Xueying; Xiao, Bing; Xu, Xiaodan; Pan, Yixuan; Xiang, Jiajia; Shao, Shiqun; Zhou, Zhuxian; Huang, Feihe; Gao, Jianqing; Slater, Nigel K. H.; Shen, Youqing; Tang, Jianbin*. Combination of Cryo-Shocked M1 Macrophages and Lonidamine Nanodrugs Enables Potent Chemo-Immunotherapy. Advanced Functional Materials, 2024, 34: e2310364.

11．Ren, Huiming; Hu, Qiuhui; Yang, Jiajia; Zhou, Xiaoxuan*; Liu, Xiangrui; Tang, Jianbin; Hu, Hongjie*; Shen, Youqing; Zhou, Zhuxian*. Single-Molecule Dendritic MRI Nanoprobes Reveal the Size-Dependent Tumor Entrance. Advanced Healthcare Materials, 2023, 12: e230221.

12．Zhou, Quan; Xiang, Jiajia; Qiu, Nasha; Wang, Yechun; Piao, Ying; Shao, Shiqun; Tang, Jianbin; Zhou, Zhuxian*; Shen, Youqing*. Tumor Abnormality-Oriented Nanomedicine Design. Chemical Reviews. 2023, 123(18): 10920-10989.

13．Yuan, Guiping; Zhang, Yifan; Shao, Shiqun; Zhou, Zhuxian; Tang, Jianbin; Xiang, Jiajia*; Shen, Youqing*. Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy. Journal of Controlled Release. 2023, 361: 792-802.

14．Ren, Huiming; Hu, Qiuhui; Sun, Yuji; Zhou, Xiaoxuan; Zhu, Yincong; Dong, Qiuyang; Chen, Linying; Tang, Jianbin; Hu, Hongjie; Shen, Youqing; Zhou, Zhuxian*. Surface chemistry mediates the tumor entrance of nanoparticles probed using single-molecule dual-imaging nanodots. Biomaterials Science. 2023, 11(21):7051-7061.

15．Hu, Qiuhui; Zhang, Bo; Ren, Huiming; Zhou, Xiaoxuan*; He, Chengbin; Shen, Youqing; Zhou, Zhuxian*; Hu, Hongjie*. Supramolecular metal-organic frameworks as host-guest nanoplatforms for versatile and customizable biomedical applications. Acta Biomaterialia, 2023, 168: 617-627.

16．Xiang, Jiajia; Liu, Kexin; Xu, Hongxia; Zhao, Zhihao; Piao, Ying; Shao, Shiqun; Tang, Jianbin; Shen, Youqing; Zhou, Zhuxian*. Dual Synergistic Tumor-Specific Polymeric Nanoparticles for Efficient Chemo-Immunotherapy. Advanced Science, 2023, 10(29):e2301216.

17．Ge, Yanni; Zhang, Jiaojiao; Jin, Kai; Ye, Ziqiang; Wang, Wei*; Zhou, Zhuxian*; Ye, Juan*. Multifunctional nanoparticles precisely reprogram the tumor microenvironment and potentiate antitumor immunotherapy after near-infrare d-II light-me diate d photothermal therapy. Acta Biomaterialia, 2023, 167:551-563.

18．Liu, Yuhang; Zhao, Yuanjiang; Zhou, Zhuxian; Shen, Youqing; Jiang, Liming*. Pore size effect of zirconium-based metal-organic frameworks for encapsulation and release of volatile monoterpenes. Colloids And Surfaces A: Physicochemical And Engineering Aspects, 2023, 674: 131907.

19．Fan, Wufa; Xiang, Jiajia; Wei, Qiuyu; Tang, Yisi; Piao, Ying; Shao, Shiqun; Zhou, Zhuxian*; Tang, Jianbin; Li, Zi-Chen*; Shen, Youqing*. Role of Micelle Size in Cell Transcytosis-Based Tumor Extravasation, Infiltration, and Treatment Efficacy. Nano Letters, 2023, 23(9): 3904-3912.

20．Yuan, Pengcheng; Xu, Xiaodan; Hu, Doudou; Chen, Yong; Fan, Jiaqi; Yao, Shasha; Piao, Ying; Zhou, Zhuxian; Shao, Shiqun; Slater, Nigel K. H.; Shen, Youqing; Tang, Jianbin*. Highly Sensitive Imaging of Tumor Metastasis Based on the Targeting and Polarization of M2-like Macrophages. Journal of The American Chemical Society, 2023, 145(14): 7941-7951.

21．Xu, Xiaodan; Wang, Rui; Li, Dongdong; Xiang, Jiajia; Zhang, Wei; Shi, Xueying; Xu, Hongxia; Yao, Shasha; Liu, Jiwei; Shao, Shiqun; Zhou, Zhuxian; Huang, Feihe; Shen, Youqing; Tang, Jianbin*. Guanidine-modified nanoparticles as robust BTZ delivery carriers and activators of immune responses. Journal of Controlled Release, 2023, 357: 310-318.

22．Huang, Jianxiang; Su, Yuexin; Buratto, Damiano; Song, Wei; Zhou, Zhuxian; Shen, Youqing; Zhou, Ruhong*. Influence of Core Topologies on Poly-L-lysine Dendrimer Structures. Journal of Physical Chemistry b, 2023, 127(15): 3364-3371.

23．Xiang, Jiajia; Shao, Shiqun; Zhou, Zhuxian*; Shen, Youqing*. “One-for-All” approach: a black technology for nanomedicine development? Medicina em Revista, 2023, 3(2):184-187.

24．Zhang, Wei; Li, Dongdong; Xu, Xiaodan; Chen, Yong; Shi, Xueying; Pan, Yixuan; Yao, Shasha; Piao, Ying; Zhou, Zhuxian; Slater, Nigel K. H.; Shen, Youqing; Tang, Jianbin*. A Bispecific Peptide-Polymer Conjugate Bridging Target-Effector Cells to Enhance Immunotherapy. Advanced Healthcare Materials, 2023, 12(18): e2202977.

25．Zhao, Zhihao; Feng, Yupu; Xiang, Jiajia; Liu, Jing; Piao, Ying; Shao, Shiqun; Tang, Jianbin; Zhou, Zhuxian*; Shen, Youqing*. Screening of Zwitterionic Liposomes with Red Blood Cell-Hitchhiking and Tumor Cell-Active Transporting Capability for Efficient Tumor Entrance. Advanced Functional Materials, 2023, 33: e2214369.

26．Bai, Haoyu; Wang, Huifang; Zhou, Zhuha*; Piao, Ying; Liu, Xiangrui; Tang, Jianbin; Shen, Xian; Shen, Youqing; Zhou, Zhuxian*. Histone Deacetylase-Triggered Self-Immolative Peptide-Cytotoxins for Cancer-Selective Drug Delivery. Advanced Functional Materials, 2023, 33: 2214025.

27．Sun, Rui; Zhang, Yifan; Lin, Xiaowei; Piao, Ying; Xie, Tao; He, Yi; Xiang, Jiajia; Shao, Shiqun; Zhou, Quan; Zhou, Zhuxian*; Tang, Jianbin; Shen, Youqing*. Aminopeptidase N-Responsive Conjugates with Tunable Charge-Reversal Properties for Highly Efficient Tumor Accumulation and Penetration. Angewandte Chemie-international Edition, 2023, 62(9): e202217408.

28．Wang, Guowei; Jiang, Yifan; Xu, Junjun; Shen, Jiaxin; Lin, Tao; Chen, Jifan; Fei, Weidong; Qin, Yating; Zhou, Zhuxian*; Shen, Youqing*; Huang, Pintong*. Unraveling the Plasma Protein Corona by Ultrasonic Cavitation Augments Active-Transporting of Liposome in Solid Tumor. Advanced Materials, 2023, 35(9): e2207271.

29．Zhang, Bo; Chen, Hongwen; Jiang, Liming; Shen, Youqing; Zhao, Dan; Zhou, Zhuxian*. A breathing A4 paper by in situ growth of green metal-organic frameworks for air freshening and cleaning. Chinese Journal of Chemical Engineering, 2022, 52: 95-102.

30．Sun, Rui; Xiang, Jiajia; Zhou, Quan; Piao, Ying; Tang, Jianbin; Shao, Shiqun; Zhou, Zhuxian*; Bae, You Han*; Shen, Youqing*. The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives. Advanced Drug Delivery Reviews, 2022, 191: 114614.

31．Zhou, Quan; Huang, Jianxiang; Hao, Lingqiao; Geng, Yu; Xu, Changhuo; Zhou, Zhuxian; Tang, Jianbin; Zhou, Ruhong*; Shen, Youqing*. Hydrophobicity Effects of γ-Glutamyl Transpeptidase-Responsive Polymers on the Catalytic Activity and Transcytosis Efficacy. Bioconjugate Chemistry, 2022, 33(11): 2132-2142.

32．Wang, Rui; Xu, Xiaodan; Li, Dongdong; Zhang, Wei; Shi, Xueying; Xu, Hongxia; Hong, Jianqiao; Yao, Shasha; Liu, Jiwei; Wei, Zhenli; Piao, Ying; Zhou, Zhuxian; Shen, Youqing; Tang, Jianbin*. Smart pH-responsive polyhydralazine/bortezomib nanoparticles for remodeling tumor microenvironment and enhancing chemotherapy. Biomaterials. 2022, 288: 121737.

33．Zhou, Quan; Li, Junjun; Xiang, Jiajia; Shao, Shiqun; Zhou, Zhuxian; Tang, Jianbin*; Shen, Youqing*. Transcytosis-enabled active extravasation of tumor nanomedicine. Advanced Drug Delivery Reviews, 2022, 189: 114480.

34．Lv, Yichao; Zhao, Yuanjiang; Liu, Yuhang; Zhou, Zhuxian; Shen, Youqing; Jiang, Liming*. Self-Assembling Oligo(2-oxazoline) Organogelators for the Encapsulation and Slow Release of Bioactive Volatiles, Acs Omega, 2022, 7(31): 27523-27531.

35．Yang, Jiajia; Wang, Kaiqi; Zheng, Yihuan; Piao, Ying; Wang, Jinqiang; Tang, Jianbin; Shen, Youqing; Zhou, Zhuxian*. Molecularly Precise, Bright, Photostable, and Biocompatible Cyanine Nanodots as Alternatives to Quantum Dots for Biomedical Applications. Angewandte Chemie-international Edition, 2022, 61(36): e202202128.

36．Xiang, Jiajia; Zhang, Yifan; Liu, Xin; Zhou, Quan; Piao, Ying; Shao, Shiqun; Tang, Jianbin; Zhou, Zhuxian*; Xie, Tao; Shen, Youqing*. Natural Polyphenols-Platinum Nanocomplexes Stimulate Immune System for Combination Cancer Therapy. Nano Letters, 2022, 22(13): 5615-5625.

37．Xiang, Jiajia; Liu, Jing; Liu, Xin; Zhou, Quan; Zhao, Zhihao; Piao, Ying; Shao, Shiqun*; Zhou, Zhuxian; Tang, Jianbin; Shen, Youqing*. Enzymatic drug release cascade from polymeric prodrug nanoassemblies enables targeted chemotherapy. Journal of Controlled Release, 2022, 348: 444-455.

38．Hu, Doudou; Zhang, Wei; Xiang, Jiajia; Li, Dongdong; Chen, Yong; Yuan, Pengcheng; Shao, Shiqun; Zhou, Zhuxian; Shen, Youqing; Tang, Jianbin*. A ROS-responsive synergistic delivery system for combined immunotherapy and chemotherapy. Materials Today Bio, 2022, 14: 100284.

39．Fan, Wufa; Wei, Qiuyu; Xiang, Jiajia; Tang, Yisi; Zhou, Quan; Geng, Yu; Liu, Yanpeng; Sun, Rui; Xu, Lei; Wang, Guowei; Piao, Ying; Shao, Shiqun*; Zhou, Zhuxian; Tang, Jianbin; Xie, Tao; Li, Zichen*; Shen, Youqing*. Mucus Penetrating and Cell-Binding Polyzwitterionic Micelles as Potent Oral Nanomedicine for Cancer Drug Delivery. Advanced Materials, 2022, 34(16): e2109189.

40．Wang, Huifang; Bai, Haoyu; Wang, Jiafeng; Zhou, Xuefei; Chen, Hongda; Wang, Liying; Ren, Huiming; Liu, Zimo; Zhuo, Wei; Zhou, Zhuxian; Tang, Jianbin; Li, Zhijie; Wang, Jigang; Shen, Youqing; Zhou, Tianhua*; Liu, Xiangrui*. Nanoprodrug ratiometrically integrating autophagy inhibitor and genotoxic agent for treatment of triple-negative breast cancer. Biomaterials, 2022, 283: 121458.

41．Xiang, Jiajia; Shen, Yihuai; Zhang, Yifan; Liu, Xin; Zhou, Quan; Zhou, Zhuxian; Tang, Jianbin; Shao, Shiqun*; Shen, Youqing*. Multipotent Poly(Tertiary Amine-Oxide) Micelles for Efficient Cancer Drug Delivery. Advanced Science, 2022, 9(12): e2200173.

42．Geng, Yu; Sun, Rui*; Zhang, Yifan; Zhou, Zhuxian; Shen, Youqing*. Copper (α)/cis-platinum-loaded nanogels as an adjuvant potentiate disulfiram's antitumor efficacy. Biomaterials Science, 2022, 10(5): 1384-1392.

43．Bai Haoyu; Zhou Zhuxian*; Shen Youqing. Self-immolative camptothecin polymeric prodrugs for controlled drug release. Journal of Chemical Engineering of Chinese Universities. 2022, 36(4): 570-578.

44．Chen, Siqin; Zhou, Quan*; Wang, Guowei; Zhou, Zhuxian; Tang, Jianbin; Xie, Tao; Shen, Youqing*. Effect of Cationic Charge Density on Transcytosis of Polyethylenimine. Biomacromolecules, 2021, 22(12): 5139-5150.

45．Liu, Kexin; Xiang, Jiajia; Wang, Guowei; Xu, Hongxia; Piao, Ying; Liu, Xiangrui; Tang, Jianbin; Shen, Youqing; Zhou Zhuxian*, Linear-Dendritic Polymer-Platinum Complexes Forming Well-Defined Nanocapsules for Acid-Responsive Drug Delivery. ACS Applied Materials & Interfaces 2021, 13, 37, 44028–44040.

46．Fang, Xinhao; Gao, Kai; Huang, Jianxiang; Liu, Kexin; Chen, Linying; Piao, Ying; Liu, Xiangrui; Tang, Jianbin; Shen, Youqing; Zhou, Zhuxian*, Molecular level precision and high molecular weight peptide dendrimers for drug-specific delivery. Journal of Materials Chemistry B 2021, 2021, 9(41): 8594-8603.

47．Zhang, Bo; Chen, Hongwen; Hu, Qiuhui; Jiang, Liming; Shen, Youqing; Zhao, Dan; Zhou, Zhuxian*, CelluMOFs: Green, Facile, and Flexible Metal-Organic Frameworks for Versatile Applications Advanced Functional Materials 2021, 31: e2105395.

48．Wang, Guowei; Zhang, Chao; Jiang, Yifan; Song, Yue; Chen, Jifan; Sun, Yu; Li, Qunying; Zhou, Zhuxian*; Shen, Youqing*; Huang, Pintong*, Ultrasonic Cavitation-Assisted and Acid-Activated Transcytosis of Liposomes for Universal Active Tumor Penetration. Advanced Functional Materials 2021, 31: e2102786.

49．Chen, Hongwen; Chen, Huaqiang; Zhang, Bo; Jiang, Liming; Shen, Youqing; Fu, Engang; Zhao, Dan; Zhou, Zhuxian*, Tuning the release rate of volatile molecules by pore surface engineering in metal-organic frameworks. Chinese Chemical Letters 2021, 32:1988-1992.

50．Zhang, Zhen; Qiu, Nasha; Wu, Shuling; Liu, Xin; Zhou, Zhuxian; Tang, Jianbin; Liu, Yanpeng; Zhou, Ruhong; Shen, Youqing*, Dose-Independent Transfection of Hydrophobized Polyplexes. Advanced Materials 2021, 33:2102219.

51．Hu, Shiqi; Jiang, Haiping; Zhu, Jianqiang; Wang, Jinqiang; Wang, Shunhao; Tang, Jianbin; Zhou, Zhuxian*; Liu, Sijin*; Shen, Youqing*, Tumor-Specific Fluorescence Activation of Rhodamine Isothiocyanate Derivatives. Journal of Controlled release 2021, 330: 842-850.

52．Hu, Doudou; Zhang, Wei; Tang, Jianbin*; Zhou, Zhuxian; Liu, Xiangrui; Shen, Youqing. Improving safety of cancer immunotherapy via delivery technology. Biomaterials 2021, 265:120407.

53．Li, Dongdong; Hu, Doudou; Xu, Hongxia; Patra, Hirak K.; Liu, Xiangrui; Zhou, Zhuxian; Tang, Jianbin*; Slater, Nigel; Shen, Youqing. Progress and perspective of microneedle system for anti-cancer drug delivery. Biomaterials 2021, 264: 120410.

54．Wang, Guowei; Wu, Bihan; Li, Qunying; Chen, Siqin; Jin, Xiaoqin; Liu, Yajing; Zhou, Zhuxian*; Shen, Youqing*; Huang, Pintong*. Active Transportation of Liposome Enhances Tumor Accumulation, Penetration, and Therapeutic Efficacy. Small 2020, 16: 2004172.

55．Hu, Shiqi; Dong, Chengyuan; Wang, Jinqiang; Liu, Kexin; Zhou, Quan; Xiang, Jiajia; Zhou, Zhuxian*; Liu, Fusheng*; Shen, Youqing*. Assemblies of Indocyanine Green and Chemotherapeutic Drug to Cure Established Tumors by Synergistic Chemo-Photo Therapy. Journal of Controlled Release 2020, 324: 250-259. 

56．Cong, Hailin; Wang, Kaiqi; Zhou, Zhuha; Yang, Jiajia; Piao, Ying; Yu, Bing; Shen, Youqing; Zhou, Zhuxian*. Tuning the Brightness and Photostability of Organic Dots for Multivalent Targeted Cancer Imaging and Surgery. ACS Nano 2020, 14: 5887-5900.

57．Wang, Guowei; Zhou, Zhuxian*; Zhao, Zhihao; Li, Qunying; Wu, Yulian; Yan, Sheng; Shen, Youqing*; Huang, Pintong*. Enzyme-Triggered Transcytosis of Dendrimer-Drug Conjugate for Deep Penetration into Pancreatic Tumors. ACS Nano 2020, 14: 4890-4904.

58．Wang, Guowei; Zhu, Dingcheng; Zhou, Zhuxian*; Piao, Ying; Tang, Jianbin; Shen, Youqing*. A Glutathione-Specific and Intracellularly Labile Polymeric Nanocarrier for Efficient and Safe Cancer Gene Delivery. ACS Applied Materials & Interfaces 2020;12:14825-14838.

59．Dong, Chengyuan; Zhou, Quan; Xiang, Jiajia*; Liu, Fusheng*; Zhou, Zhuxian*; Shen, Youqing. Self-assembly of Oxidation-Responsive Polyethylene Glycol-Paclitaxel Prodrug for Cancer Chemotherapy. Journal of Controlled Release, 2020, 321: 529-539.

60．Wang Jiafeng, Zhou Xuefei , Wang Huifang, Xiao Qian, Ding Kefeng, Dong Xue, Xu Shufeng, Shen Bo, Sun Jihong, Zhou Zhuxian, Tang Jianbin, Liu Xiangrui*, Shen Youqing. Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability. Biomaterials, 2020, 255: 120156.

61．Wang, Kaojin; Amin, Kamran; An, Zesheng; Cai, Zhengxu; Chen, Hong; Chen, Hongzheng; Dong, Yuping; Feng, Xiao; Fu, Weiqiang; Gu, Jiabao; Han, Yanchun; Hu, Doudou; Hu, Rongrong; Huang, Die; Huang, Fei; Huang, Feihe; Huang, Yuzhang; Jin, Jian; Jin, Xin; Li, Qianqian; Li, Tengfei; Li, Zhen; Li, Zhibo; Liu, Jiangang; Liu, Jing; Liu, Shiyong; Peng, Huisheng; Qin, Anjun; Qing, Xin; Shen, Youqing; Shi, Jianbing; Sun, Xuemei; Tong, Bin; Wang, Bo; Wang, Hu; Wang, Lixiang; Wang, Shu; Wei, Zhixiang; Xie, Tao; Xu, Chunye; Xu, Huaping; Xu, Zhi-Kang; Yang, Bai; Yu, Yanlei; Zeng, Xuan; Zhan, Xiaowei; Zhang, Guangzhao; Zhang, Jie; Zhang, Ming Qiu; Zhang, Xian-Zheng; Zhang, Xiao; Zhang, Yi; Zhang, Yuanyuan; Zhao, Changsheng; Zhao, Weifeng; Zhou, Yongfeng; Zhou, Zhuxian; Zhu, Jintao; Zhu, Xinyuan; Tang, Ben Zhong*. Advanced functional polymer materials. Materials Chemistry Frontiers, 2020, 4: 1803-1915.

62．Tian, Dan; Xu, Hongxia; Xiao, Bing; Zhou, Xiaoxuan; Liu, Xiangrui; Zhou, Zhuxian; Patra, Hirak K.*; Slater, Nigel; Tang, Jianbin*; Shen, Youqing. Single-Step Formulation of Levodopa-Based Nanotheranostics–Strategy for Ultra-Sensitive High Longitudinal Relaxivity MRI Guided Switchable Therapeutics. Biomaterials Science, 2020, 8: 1615-1621.

63．Xiao, Bing; Zhou, Xiaoxuan; Xu, Hongxia; Zhang, Wei; Xu, Xiaodan; Tian, Fengjuan; Qian, Yue; Yu, Feidan; Pu, Cailing; Hu, Hongjie; Zhou, Zhuxian; Liu, Xiangrui; Patra, Hirak K.; Slater, Nigel; Tang, Jianbin*; Gao, Jianqing; Shen, Youqing. On/off switchable epicatechin-based ultra-sensitive MRI-visible nanotheranostics – see it and treat it. Biomaterials Science, 2020, 8: 5210-5218.

64．Li, Zixie; Huang, Jianxiang; Ye, Long; Lv, Yichao; Zhou, Zhuxian; Shen, Youqing; He, Yi; Jiang, Liming*. Encapsulation of Highly Volatile Fragrances in Y Zeolites for Sustained Release: Experimental and Theoretical Studies. ACS Omega, 2020, 5: 31925-31935.

65．Hu, Doudou; Li, Dongdong; Liu, Xiangrui; Zhou, Zhuxian; Tang, Jianbin*; Shen, Youqing. Vanadium-based nanomaterials for cancer diagnosis and treatment. Biomedical Materials, 2020, 16: 014101.

66．Wang, Sihang; Jiang, Dong; Zhou, Zhuxian; Shen, Youqing; Jiang, Liming*. A novel photothermo-responsive nanocarrier for the controlled release of low-volatile fragrances. RSC Advances, 2020, 10: 14867-14876.

67．Liu, Yiqiao; Gargesha, Madhu; Qutaish, Mohammed; Zhou, Zhuxian; Scott, Bryan; Yousefi, Hamed; Lu, Zhengrong; Wilson, David L.*. Deep learning based multi-organ segmentation and metastases segmentation in whole mouse body and the cryo-imaging cancer imaging and therapy analysis platform (CITAP). SPIE-Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging, 2020, 11317: 113170V.

68．Wang, Jinqiang; Hu, Shiqi; Mao, Weiwei; Xiang, Jiajia; Zhou, Zhuxian*; Liu, Xiangrui; Tang, Jianbin; Shen, Youqing. Assemblies of Peptide-Cytotoxin Conjugates for Tumor Homing Chemotherapy. Advanced Functional Materials, 2019, 29: 1807446.

69．Zhou, Zhuha; Piao, Ying; Hao, Lingqiao; Wang, Guanyu*; Zhou, Zhuxian*; Shen, Youqing. Acidity-Responsive Shell-Sheddable Camptothecin-based Nanofibers for Carrier-free Cancer Drug Delivery. Nanoscale, 2019, 11: 15907-15916.

70．Huang Jianxiang, Wu Bihan, Zhou Zhuxian*, Hu Shiqi, Xu Hongxia, Piao Ying, Zheng Hao*, Tang Jianbin, Liu Xiangrui, Shen Youqing. Drug-Binding Albumins Forming Stabilized Nanoparticles for Efficient Anticancer Therapy. Nanomedicine: Nanotechnology, Biology and Medicine, 2019, 21: 102058.

71．Zhou, Quan; Shao, Shiqun; Wang, Jinqiang; Xu, Changhuo; Xiang, Jiajia; Piao, Ying; Zhou, Zhuxian; Yu, Qingsong; Tang, Jianbin; Liu, Xiangrui; Gan, Zhihua; Mo, Ran; Gu, Zhen*; Shen, Youqing*. Enzyme-Activatable Polymer–Drug Conjugate Augments Tumour Penetration and Treatment Efficacy. Nature Nanotechnology, 2019, 14: 799-809.

72．Liu, Yuhang; Wang, Yuxiang; Huang, Jianxiang; Zhou, Zhuxian*; Zhao, Dan; Jiang, Liming; Shen, Youqing. Encapsulation and Controlled Release of Fragrances from Functionalized Porous Metal–Organic Frameworks. AIChE Journal, 2019, 65: 491-499.

73．Zhang, Bo; Huang, Jianxiang; Liu, Kexin; Zhou, Zhuxian*; Jiang, Liming; Shen, Youqing; Zhao, Dan. Biocompatible Cyclodextrin-Based Metal-Organic Frameworks for Long-Term Sustained Release of Fragrances. Industrial & Engineering Chemistry Research, 2019, 58: 19767-19777.

74．Ye, Long; Li, Zixie; Niu, Rui; Zhou, Zhuxian; Shen, Youqing; Jiang, Liming*. All-Aqueous Direct Deposition of Fragrance-Loaded Nanoparticles onto Fabric Surfaces by Electrospraying. ACS Applied Polymer Materials, 2019, 1: 2590-2596.

75．Han, Yuxin; Zhou, Xiaoxuan; Qian, Yue; Hu, Hongjie; Zhou, Zhuxian; Liu, Xiangrui; Tang, Jianbin*; Shen, Youqing. Hypoxia-targeting dendritic MRI contrast agent based on internally hydroxy dendrimer for tumor imaging. Biomaterials, 2019, 213: 119195.

76．Zhou, Xuefei; Liu, Zimo; Wang, Huifang; Liu, Xin; Zhou, Zhuxian; Tang, Jianbin; Liu, Xiangrui*; Zheng, Min; Shen, Youqing. SAHA (vorinostat) Facilitates Functional Polymer-based Gene Transfection via Upregulation of ROS and Synergizes with TRAIL Gene Delivery for Cancer Therapy. Journal of Drug Targeting, 2019, 27: 306-314.

77．Wang Yue; Zhou Zhuxian; Shen Youqing*. Construction and evaluation of gene delivery system based on polyacylthiourea. Journal of ZheJiang University (Engineering Science), 2019, 53(3): 598-604.

78．Xiang, Jiajia; Liu, Xin; Zhou, Zhuxian*; Zhu, Dingcheng; Zhou, Quan; Piao, Ying; Jiang, Liming; Tang, Jianbin; Liu, Xiangrui; Shen, Youqing. Reactive Oxygen Species (ROS)-Responsive Charge-Switchable Nanocarriers for Gene Therapy of Metastatic Cancer. ACS Applied Materials & Interfaces, 2018, 10: 43352-43362.

79．Yan, Huijie; Zhu, Dingcheng; Zhou, Zhuxian*; Liu, Xin; Piao, Ying; Zhang, Zhen; Liu, Xiangrui; Tang, Jianbin; Shen, Youqing*. Facile Synthesis of Semi-Library of Low Charge Density Cationic Polyesters from Poly(alkylene maleate)s for Efficient Local Gene Delivery. Biomaterials, 2018, 178: 559-569.

80．Zhou, Quan; Wang, Yue; Xiang, Jiajia; Piao, Ying; Zhou, Zhuxian*; Tang, Jianbin; Liu, Xiangrui; Shen, Youqing*. Stabilized Calcium Phosphate Hybrid Nanocomposite using a Benzoxaborole-containing Polymer for pH-Responsive siRNA Delivery. Biomaterials Science, 2018, 6: 3178-3188.

81．Zhang, Zhen; Zhou, Yongcun; Zhou, Zhuxian*; Piao, Ying; Kalva, Nagendra; Liu, Xiangrui; Tang, Jianbin; Shen, Youqing*. Synthesis of Enzyme-Responsive Phosphoramidate Dendrimers for Cancer Drug Delivery. Polymer Chemistry, 2018, 9: 438-449.

82．Xiang, Jiajia; Wu, Bihan; Zhou, Zhuxian*; Hu, Shiqi; Piao, Ying; Zhou, Quan; Wang, Guowei; Tang, Jianbin; Liu, Xiangrui; Shen, Youqing*. Synthesis and Evaluation of a Paclitaxel-Binding Polymeric Micelle for Efficient Breast Cancer Therapy. Science China-Life Sciences, 2018, 61: 436-447.

83．Xiao, Bing; Zhou, Xiaoxuan; Xu, Hongxia; Wu, Bihan; Hu, Ding; Hu, Hongjie; Pu, Kanyi; Zhou, Zhuxian; Liu, Xiangrui; Tang, Jianbin*; Shen, Youqing. Integration of Polymerization and Biomineralization as a Strategy to Facilely Synthesize Nanotheranostic Agents. ACS Nano, 2018, 12: 12682-12691.

84．Hu, Ding; Xu, Hongxia; Xiao, Bing; Li, Dongdong; Zhou, Zhuxian; Liu, Xiangrui; Tang, Jianbin*; Shen, Youqing. Albumin-Stabilized Metal–Organic Nanoparticles for Effective Delivery of Metal Complex Anticancer Drugs. ACS Applied Materials & Interfaces, 2018, 10: 34974-34982.

85．Liu, Yuxi; Liu, Keyuan; Zhao, Mengna; Wang, Sihang; Zhou, Zhuxian; Shen, Youqing; Jiang, Liming*. A pH-Responsive Fragrance Release System Based on Pseudopeptide Polymeric Micelles. Reactive and Functional Polymers, 2018, 132: 138-144.

86．Jiang, Haiping; Wang, Sujuan; Zhou, Xuefei; Wang, Liying; Ye, Lidan; Zhou, Zhuxian; Tang, Jianbin; Liu, Xiangrui*; Teng, Lisong; Shen, Youqing. New Path to Treating Pancreatic Cancer: TRAIL Gene Delivery Targeting the Fibroblast-Enriched Tumor Microenvironment. Journal of Controlled Release, 2018, 286: 254-263.

87．Zhu, Dingcheng; Yan, Huijie; Zhou, Zhuxian; Tang, Jianbin; Liu, Xiangrui; Hartmann, Raimo; Parak, Wolfgang J.; Feliu, Neus*; Shen, Youqing*. Detailed Investigation on How the Protein Corona Modulates the Physicochemical Properties and Gene Delivery of Polyethylenimine (PEI) Polyplexes. Biomaterials Science, 2018, 6:1800-1817.

88．Han, Zheng; Cheng, Han; Parvani, Jenny G.; Zhou, Zhuxian; Lu, Zheng-Rong*. Magnetic Resonance Molecular Imaging of Metastatic Breast Cancer by Targeting Extradomain-B Fibronectin in the Tumor Microenvironment. Magnetic Resonance in Medicine, 2018, 79: 3135-3143.

89．Zhou, Zhuxian; Liu, Xiangrui; Zhu, Dingcheng; Wang, Yue; Zhang, Zhen; Zhou, Xuefei; Qiu, Nasha; Chen, Xuesi; Shen, Youqing*. Nonviral Cancer Gene Therapy: Delivery Cascade and Vector Nanoproperty Integration. Advanced Drug Delivery Reviews, 2017, 115: 115-154.

90．Sun, Qihang; Zhou, Zhuxian; Qiu, Nasha; Shen, Youqing*. Rational design of cancer nanomedicine: Nanoproperty integration and synchronization. Advanced Materials, 2017, 29: 1606628.

91．Zhu, Dingcheng; Yan, Huijie; Liu, Xin; Xiang, Jiajia; Zhou, Zhuxian*; Tang, Jianbin; Liu, Xiangrui; Shen, Youqing*. Intracellularly disintegratable polysulfoniums for efficient gene delivery. Advanced Functional Materials, 2017; 27: 1606826.

92．Zhou, Zhuxian*; Lu, Zheng-Rong*. Molecular Imaging of the tumor microenvironment. Advanced Drug Delivery Reviews, 2017, 113: 24-48.

93．Xia, Mingchun; Ye, Mingzhou; Zhou, Xiaoxuan; Tang, Jianbin*; Piao, Ying; Liu, Xiangrui; Zhou, Zhuxian; Hu, Hongjie; Shen, Youqing. A facile synthesis of a theranostic nanoparticle by oxidation of dopamine-DTPA-Gd conjugates. Journal of Materials Chemistry B, 2017, 5: 8754-8760.

94．Ye, Mingzhou; Han, Yuxin; Tang, Jianbin*; Piao, Ying; Liu, Xiangrui; Zhou, Zhuxian; Gao, Jianqing*; Rao, Jianghong*; Shen, Youqing. A tumor-specific cascade amplification drug release nanoparticle for overcoming multidrug resistance in cancers. Advanced Materials 2017; 29:1702342.

95．Wang, Liying; Liu, Xiangrui*; Zhou, Quan; Sui, Meihua; Lu, Zipeng; Zhou, Zhuxian; Tang, Jianbin; Miao, Yi; Zheng, Min; Wang, Weilin; Shen, Youqing. Terminating the criminal collaboration in pancreatic cancer: Nanoparticle-based synergistic therapy for overcoming fibroblast-induced drug resistance. Biomaterials, 2017, 144: 105-118.

96．Han, Zheng; Li, Yajuan; Roelle, Sarah; Zhou, Zhuxian; Liu, Yuchi; Sabatelle, Rob; DeSanto, Aidan; Yu, Xin; Zhu, Hui; Magi-Galluzzi, Cristina; Lu, Zheng-Rong*. A targeted contrast agent specific to an oncoprotein in tumor microenvironment with the potential for detection and risk stratification of prostate cancer with MRI. Bioconjugate Chemistry, 2017, 28: 1031-1040.

97．Zhou Zhuxian, Han Zheng, Lu Zheng-Rong*. A targeted nanoglobular contrast agent from host-guest self-assembly for MR cancer molecular imaging. Biomaterials, 2016, 85: 168-179.

98．Xi, Xiujuan; Hu, Shiqi; Zhou, Zhuxian*; Liu, Xiangrui; Tang, Jianbin; Shen, Youqing*.  Dendrimers with protocatechuic acid building blocks for anticancer drug delivery. Journal of Materials Chemistry B, 2016, 4: 5236-5245.

99．Zhou, Zhuxian*; Murdoch, William J.; Shen, Youqing*. Synthesis of an esterase-sensitive degradable polyester as facile drug carrier for cancer therapy. Journal of Polymer Science, Part A: Polymer Chemistry, 2016, 54: 507-515.

100．Qiu, Nasha; Liu, Xiangrui; Zhong, Yin; Zhou, Zhuxian; Piao, Ying; Miao, Lei; Zhang, Qianzhi; Tang, Jianbin; Huang, Leaf; Shen, Youqing*. Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy. Advanced Materials, 2016, 28: 10613-10622.

101．Han, Yuxin; Qian, Yue; Zhou, Xiaoxuan; Hu, Hongjie; Liu, Xiangrui; Zhou, Zhuxian; Tang, Jianbin*; Shen, Youqing. Facile synthesis of zwitterionic polyglycerol dendrimers with a β-cyclodextrin core as MRI contrast agent carriers. Polymer Chemistry, 2016, 7: 6354-6362.

102．Ye, Zhen; Zhou, Zhuxian; Ayat, Nadia; Wu, Xueming; Jin, Erlei; Shi, Xiaoyue; Lu, Zheng-Rong*. A neutral polydisulfide containing Gd (III) DOTA monoamide as a redox‐sensitive biodegradable macromolecular MRI contrast agent. Contrast Media & Molecular Imaging, 2016, 11: 32-40.

103．Zhao, Bin-wei; Zhou, Zhuxian; Shen, Youqing*. Effects of chirality on gene delivery efficiency of polylysine. Chinese Journal of Polymer Science, 2016, 34: 94-103.

104．Sun, Qihang; Ma, Xinpeng; Zhang, Bo; Zhou, Zhuxian; Jin, Erlei; Shen, Youqing*; Van Kirk, Edward A.; Murdoch, William J.; Radosz, Maciej; Sun, Weilin*. Fabrication of dendrimer-releasing lipidic nanoassembly for cancer drug delivery. Biomaterials Science, 2016, 4: 958-969.

105．Zhou, Xuefei; Liu, Xiangrui*; Zhao, Bingxiang; Liu, Xin; Zhu, Dingcheng; Qiu, Nasha; Zhou, Quan; Piao, Ying; Zhou, Zhuxian; Tang, Jianbin; Shen, Youqing. Jumping the nuclear envelop barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306. Journal of Controlled Release, 2016, 234: 90-97.

106．Zhou, Zhuxian; Qutaish, Mohammed; Han, Zheng; Schur, Rebecca M.; Liu, Yiqiao; Wilson, David L.*; Lu, Zheng-Rong*. MRI detection of breast cancer micrometastases with a  fibronectin-targeting contrast agent. Nature Communications, 2015, 6: 7984

107．Zhou, Zhuxian; Mondjinou, Yawo; Hyun, Seok-Hee; Kulkarni, Aditya; Lu, Zheng-Rong*; Thompson, David H.*. Gd3+-DOTA-beta-cyclodextrin/pluronic polyrotaxane as a long circulating high relaxivity MRI contrast agent. ACS Applied Materials & Interfaces, 2015, 7: 22272-22276.

108．Zhou, Zhuxian; Tang, Jianbin; Sun, Qihang; Murdoch, William J.; Shen, Youqing*. A multifunctional PEG-PLL drug conjugate forming redox-responsive nanoparticle for intracellular drug delivery. Journal of Materials Chemistry B, 2015, 3: 7594-7603.

109．Zhou, Zhuxian*; Murdoch, William J.; Shen, Youqing*. A linear polyethylenimine (LPEI) drug conjugate with reversible charge to overcome multidrug resistance in cancer cells. Polymer, 2015, 76: 150-158.

110．Liu, Xin; Xiang, Jiajia; Zhu, Dingcheng; Jiang, Liming; Zhou, Zhuxian; Tang, Jianbin; Liu, Xiangrui; Huang, Yongzhuo; Shen, Youqing*. Fusogenic Reactive Oxygen Species Triggered Charge‐Reversal Vector for Effective Gene Delivery. Advanced Materials, 2016, 28: 1743-1752.

111．Hu, Shiqi; Lee, Eunhye; Wang, Chi; Wang, Jinqiang; Zhou, Zhuxian; Li, Yixian; Li, Xiaoyi; Tang, Jianbin; Lee, Don Haeng; Liu, Xiangrui; Shen, Youqing*. Amphiphilic drugs as surfactants to fabricate excipient-free stable nanodispersions of hydrophobic drugs for cancer chemotherapy. Journal of Controlled Release, 2015, 220: 175-179.

112．Han, Zheng; Zhou, Zhuxian; Shi, Xiaoyue; Wang, Junpeng; Wu, Xiaohui; Sun, Da; Chen, Yinghua; Zhu, Hui; Magi-Galluzzi, Cristina; Lu, Zheng-Rong*. An EDB fibronectin specific peptide for prostate cancer targeting. Bioconjugate Chemistry, 2015, 26: 830-838.

113．Zhou, Zhuxian; Ma, Xinpeng; Murphy, Caitlin J.; Jin, Erlei; Sun, Qihang; Shen, Youqing*; Van Kirk, Edward A.; Murdoch, William J.. Murdoch. Molecularly precise dendrimer-drug conjugates with tunable drug release for cancer Therapy. Angewandte Chemie International Edition, 2014, 53: 10949-10955.

114．Zhou, Zhuxian; Lu, Zheng-Rong*. Dendritic nanoglobules with POSS core and their biomedical applications. Nanomedicine, 2014, 9: 2387-2401.

115．Sun, Qihang; Sun, Xuanrong; Ma, Xinpeng; Zhou, Zhuxian; Jin, Erlei; Zhang, Bo; Shen, Youqing*; Van Kirk, Edward A.; Murdoch, William J.; Lott, Joseph R.; Lodge, Timothy P.; Radosz, Maciej; Zhao, Yuliang*. Integration of Nanoassembly Functions for Effective Cancer Drug Delivery Cascade. Advanced Materials, 2014, 26: 7615-7621.

116．Zhou, Zhuxian; Ma, Xinpeng; Jin, Erlei; Tang, Jianbin; Sui, Meihua; Shen, Youqing*; Van Kirk, Edward A.; Murdoch, William J.; Radosz, Maciej. Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery. Biomaterials, 2013, 34: 5722-5735.

117．Zhou, Zhuxian; Wu, Xueming; Kresak, Adam; Griswold, Mark; Lu, Zheng-Rong*. Peptide targeted tripod macrocyclic Gd(III) chelates for cancer molecular MRI. Biomaterials, 2013, 34: 7683-7693.

118．Zhou, Zhuxian; Lu, Zheng-Rong*. Gadolinium-based contrast agents for magnetic resonance cancer imaging. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnolgy, 2013, 5: 1-18.

119．Burden-Gulley, Susan M.; Zhou, Zhuxian; Craig, Sonya E. L.; Lu, Zheng-Rong*; Brady-Kalnay, Susann M.*. Molecular magnetic resonance imaging of tumors with a PTPmicro targeted contrast agent. Translational Oncology, 2013, 6: 329-337.

120．Ma, Xinpeng; Sun, Qihang; Zhou, Zhuxian; Jin, Erlei; Tang, Jianbin; Van Kirk, Edward; Murdoch, William J.; Shen, Youqing*. Synthesis of degradable bifunctional dendritic polymers as versatile drug carriers. Polymer Chemistry, 2013, 4: 812-819.

121．Jin, Erlei; Zhang, Bo; Sun, Xuanrong; Zhou, Zhuxian; Ma, Xinpeng; Sun, Qihang; Tang, Jianbin; Shen, Youqing*; Van Kirk, Edward; Murdoch, William J.; Radosz, Maciej. Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery. Journal of the American Chemical Society, 2013, 135: 933-940.

122．Wu, Xueming; Yu, Guanping; Luo, Chengcai; Maeda, Akiko; Zhang, Ning; Sun, Da; Zhou, Zhuxian; Puntel, Anthony; Palczewski, Krzysztof; Lu, Zheng-Rong*. Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic acid conjugate with a hydrolyzable Schiff base spacer for treating retinal degeneration. ACS Nano, 2013, 8: 153-161.

123．Ma, Xinpeng; Zhou, Zhuxian; Jin, Erlei; Sun, Qihang; Zhang, Bo; Tang, Jianbin; Shen, Youqing*. Facile synthesis of polyester dendrimers as drug delivery carriers. Macromolecules, 2012, 46: 37-42.

124．Zhou, Zhuxian; Shen, Youqing*; Tang, Jianbin; Jin, Erlei; Ma, Xinpeng; Sun, Qihang; Zhang, Bo; Van Kirk, Edward A.; Murdoch, William J.. Linear polyethyleneimine-based charge-reversal nanoparticles for nuclear-targeted drug delivery. Journal of Materials Chemistry, 2011, 21: 19114-19123.

125．Shen, Youqing*; Ma, Xinpeng; Zhang, Bo; Zhou, Zhuxian; Sun, Qihang; Jin, Erlei; Sui, Meihua; Tang, Jianbin; Wang, Jinqiang; Fan, Maohong. Degradable dual pH- and temperature-responsive photoluminescent dendrimers. Chemistry-A European Journal, 2011, 17: 5319-5326.

126．Shen, Youqing*; Zhou, Zhuxian; Sui, Meihua; Tang, Jianbin; Xu, Peisheng; Van Kirk, Edward A.; Murdoch, William J.; Fan, Maohong; Radosz, Maciej. Charge-reversal polyamidoamine dendrimer for cascade nuclear drug delivery. Nanomedicine, 2010, 5: 1205-1217.

127．Zhou, Zhuxian; Shen, Youqing*; Tang, Jianbin; Fan, Maohong; Van Kirk, Edward A.; Murdoch, William J.; Radosz, Maciej. Charge-reversal drug conjugate for targeted cancer cell nuclear drug delivery. Advanced Functional Materials, 2009, 19: 3580-3589.

128．Zhou, Zhuxian; Sun, Weilin*; Tang, Jianbin; Shen, Zhiquan. Synthesis of novel copolymers containing tri(ethylene oxide) segments and bithiazole rings on the backbone and magnetic properties of their complexes. Polymer, 2006, 47: 6280-6284.

129．Yang, Jun; Sun, Weilin*; Zhou, Zhuxian; Shen, Zhiquan. Synthesis and properties of polymeric complexes containing bithiazole rings and carbazole units. Journal of Applied Polymer Science, 2006, 101: 443-446.

130．Zhou, Zhuxian; Sun, Weilin*; Tang, Jianbin; Shen, Zhiquan. Synthesis and properties of novel fully conjugated polymers containing bithiazole rings. Polymer, 2005, 46: 9496-9500.