申有青，教育部长江学者特聘教授、国家杰青、浙江大学求是特聘教授、化工学院院长、智能生物材料浙江省重点实验室主任。于1991、1995年分别获浙江大学理学学士和博士学位，获首届《全国优博论文奖》；02年获加拿大McMaster University工学博士学位。02年起任美国怀俄明大学（University of Wyoming）助理教授，07年被破格晋升为tenured副教授，08年受邀回国任浙江大学求是学者教授和生物纳米工程中心主任，获08年的杰青资助，入选科技部中青年科技创新领军人才、教育部长江学者特聘教授。主要从事功能高分子合成及其应用于纳米药物的研究。在美国执教期间主持美国国家科学基金等项目10余项，回国后主持国家杰青、973前期及基金委重大项目课题和重点项目、国家重大科学研究计划项目和国家重点研发计划项目（首席科学家）等。在Nature Nanotechnology、Nature Biomedical Engineering、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.和Adv. Mater.等国际著名学术期刊上发表SCI论文600余篇，出版RSC和Wiley著作各1部，获10余项中美专利，2个高分子基纳米药物获美国临床试验批件，其中一个进入临床II期，另获2个中国药监局临床试验批件。 

 兼美国化学会化工领域top期刊 Chem&Bio Engineering 执行主编，Advanced Drug Delivery Review (IF 15) Executive Editor，中国生物材料学会生物医用高分子分会副主任委员，中国药学会纳米药物专业委员会副主任委员、中国医药生物技术协会生物纳米技术分会副主任委员及多个期刊编委，入选美国Fellow of American Institute of Biological and Medical Engineering (2018)，2015年起连续入选中国高被引学者榜。以第一完成人获2023年国家自然科学奖二等奖、2021年浙江省自然科学奖一等奖。

1.接受高等教育情况

2.研究领域 

高分子合成、生物医用高分子；树状高分子合成；肿瘤靶向药物/基因输送；化学生物学

3.奖励和荣誉等

中国化学会侯德榜创新奖（2024）

国家自然科学奖二等奖（1/5，2024）

浙江省首届知识产权奖（1/3，2023）

浙江省有突出贡献的中青年专家（2023）

浙江省自然科学奖一等奖（1/5，2021）

教育部长江学者特聘教授（2015）

国家杰出青年科学基金获得者（2008）

全国优秀博士学位论文（指导教师：沈之荃院士，1999）

4.研究项目基金

国家杰出青年科学基金50888001：载体与缓释材料，2009.1-2012.12，200万RMB，负责人.

国家自然科学基金委面上基金20974096：癌细胞核逐级靶向的聚合物－药物键合物作为癌靶向药物载体的研究，2009.1-2011.12，34万RMB，负责人.

973 计划前期研究专项2009CB526403：利用肿瘤细胞核靶向药物输送克服肿瘤抗药性的研究，2009.4.-2011.4，66万RMB，主持.

国家自然科学基金委重大项目：课题2：新型拓扑高分子的高效合成21090352，2011.1-2014.12，课题二主持人，260万RMB.

国家自然科学基金委重大项目：课题1：高分子纳米载体结构与体内药物输送特定过程的相关性研究51390481，2014.1-2018.12，课题二子负责人，总经费590万，本人负责290万RMB.

科技部国家重大科学研究计划纳米专项2014CB931900：核酸药物高效纳米载药系统的研究，2014.1-2018.12，首席科学家及课题一负责人，总经费1490万.

国家自然科学基金委-广东省联合基金：作用于肿瘤微环境的无毒抗肿瘤高分子的设计，2016.1-2020.12，主持，290万.

国家自然科学基金委重点项目51833008：酶响应电荷反转聚合物的设计与高疗效抗肿瘤纳米药物的构建，2019.1-2023.12，主持，300万元.

科技部国家重大科学研究计划纳米专项2021YFA1201200：肿瘤主动渗透型智能纳米药物的创制与临床转化，2022.1-2026.12，主持，1800万元.

5.代表性论文

1. Q. Zhou, J. Xiang, N. Qiu, Y. Wang, Y. Piao, S. Shao, J. Tang, Z. Zhou, and Y. Shen, Chemical Reviews, 2023, 123, 10920-10989.

2. R. Zhang, S. Shao, Y. Piao, J. Xiang, X. Wei, Z. Zhang, Z. Zhou, J. Tang, N. Qiu, X. Xu, Y. Liu, and Y. Shen, Advanced Materials, 2023, 2303614

3. W. Fan, J. Xiang, Q. Wei, Y. Tang, Y. Piao, S. Shao, Z. Zhou, J. Tang, Z.-C. Li and Y. Shen, Role of Micelle Size in Cell Transcytosis-Based Tumor Extravasation, Infiltration, and Treatment Efficacy,  Nano Letters (2023) in press.

4. Y. Shen and Y.H. Bae, Tumour Extravasation of Nanomedicine: the EPR and Alternative Pathways. Advanced Drug Delivery Review  (2023), p. 114707.

5. R. Sun, J. Xiang, Q. Zhou, Y. Piao, J. Tang, S. Shao, Z. Zhou, Y.H. Bae and Y. Shen, The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives, Advanced Drug Delivery Reviews (2022), p. 114614.

6. R. Sun, Y. Zhang, X. Lin, Y. Piao, T. Xie, Y. He, J. Xiang, S. Shao, Q. Zhou and Z. Zhou, Aminopeptidase N‐Responsive Conjugates with Tunable Charge‐Reversal Properties for Highly Efficient   Tumor Accumulation and Penetration, Angewandte Chemie (2023) in press.

7. G. Wang, Y. Jiang, J. Xu, J. Shen, T. Lin, J. Chen, W. Fei, Y. Qin, Z. Zhou and Y. Shen, Unraveling the Plasma Protein Corona by Ultrasonic Cavitation Augments Active‐Transporting of Liposome in  Solid Tumor, Advanced Materials 35 (2023), p. 2207271.

8. J. Xiang, S. Shao, Z. Zhou and Y. Shen, “One-for-All” approach: a black technology for nanomedicine development?, Medical Review (2023).

9. Z. Zhao, Y. Feng, J. Xiang, J. Liu, Y. Piao, S. Shao, J. Tang, Z. Zhou and Y. Shen, Screening of Zwitterionic Liposomes with Red Blood Cell‐Hitchhiking and Tumor Cell‐Active Transporting Capability for Efficient Tumor Entrance, Advanced Functional Materials (2023), p. 2214369.

10. W. Fan, Q. Wei, J. Xiang, Y. Tang, Q. Zhou, Y. Geng, Y. Liu, R. Sun, L. Xu, G. Wang, Y. Piao, S. Shao*, Z. Zhou, J. Tang, T. Xie, Z. Li,* Y. Shen*, Mucus Penetrating and Cell-binding Polyzwitterionic Micelles as Potent Oral Nanomedicine for Cancer Drug Delivery, Advanced Materials, 2022, 2109189.

11. S. Chen, Y. Zhong, W. Fan, J. Xiang, G. Wang, Q. Zhou, J. Wang, Y. Geng, R. Sun, Z. Zhang, Y. Piao, J. Wang, J. Zhuo, H. Cong, H. Jiang, J. Ling, Z. Li, D. Yang, X. Yao, X. Xu, Z. Zhou, J. Tang, Y.Q. Shen*, Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity, Nature Biomedical Engineering  2021, 5 (9), 1019-1037.

12. J. Liu, Z. Zhao, N. Qiu, Q. Zhou, G. Wang, H. Jiang, Y. Piao, Z. Zhou, J. Tang, Y.Q. Shen, Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy, Nature communications 2021, 12, 2425.

13. Q. Zhou, S.Q. Shao, J.Q. Wang, C. Xu, J.J. Xiang, Y. Piao, Z.X. Zhou, Q.S. Yu, J.B. Tang, X.R. Liu, Z.H. Gan, Z.  Gu,* and Y.Q. Shen*, Enzyme-Activatable Polymer-Drug Conjugate Augments Tumour Penetration and Treatment Efficacy, Nature Nanotechnology, 2019, 14, 799-809. https://doi.org/10.1038/s41565-019-0485-z.

14. X-C. Jiang, J.-J. Xiang, H. H. Wu, T. Y. Zhang, D. P. Zhang, Q. H. Xu, X.L. Huang, X.L. Kong, J.H. Sun, Y.L. Hu, K. Li, Y. Tabata, Y. Q. Shen*, J. Q. Gao*, Neural Stem Cells Transfected with Reactive Oxygen Species-Responsive Polyplexes for Effective Treatment of Ischemic Stroke, Advanced materials, 10.1002/adma.201807591

15. Q. Zhou, Y. Wang, J.J. Xiang, Y. Piao, Z.X. Zhou*, J.B. Tang, X.R. Liu, Y. Shen*, Stabilized calcium phosphate hybrid nanocomposite using a benzoxaborole-containing polymer for pH-responsive siRNA delivery, Biomaterials Science 2018, 6, 3178-3188

16. X. Sun, G. Wang, H. Zhang, S. Hu, X. Liu, J. Tang, Y. Shen*, The blood clearance kinetics and pathway of polymeric micelles in cancer drug delivery, ACS Nano 2018, 12, 6179-6192.

17. H. Yan, D. Zhu, Z. Zhou, X. Liu, Y. Piao, Z. Zhang, X. Liu, J. Tang, Y. Shen*, Facile synthesis of semi-library of low charge density cationic polyesters from poly(alkylene maleate)s for efficient local gene delivery, Biomaterials 2018, 178, 559-569.

18. N. Qiu, J. Gao, Q. Liu, J. Wang, Y. Shen*, Enzyme-responsive charge-reversal polymer-mediated effective gene therapy for intraperitoneal tumors, Biomacromolecules 2018, 19, 2308-2319.

19. D. Zhu, H. Yan, Z. Zhou, J. Tang, X. Liu, R. Hartmann, W.J. Parak, N. Feliu*, Y. Shen*, Detailed investigation on how the protein corona modulates the physicochemical properties and gene delivery of polyethylenimine (PEI) polyplexes, Biomaterials Science 2018, 6, 1800-1817.

20. H.P. Jiang, S.J. Wang, X.F. Zhou, L.Y. Wang, L.D. Ye, Z.X. Zhou, J.B. Tang, X.R. Liu, L.S. Teng, Y. Shen, New path to treating pancreatic cancer: TRAIL gene delivery targeting the fibroblast-enriched tumor microenvironment, Journal of Controlled Release 2018, 286, 254-263.

21. Y. Zhou, F. Huang, Y. Yang, P. Wang, Z. Zhang, Y. Tang, Y. Shen, K. Wang, Paraptosis-inducing nanomedicine overcomes cancer drug resistance for a potent cancer therapy, Small 2018, 14, online.

22. Z. Zhang, Y. Zhou, Z. Zhou*, Y. Piao, N. Kalva, X. Liu, J. Tang, Y. Shen*, Synthesis of enzyme-responsive phosphoramidate dendrimers for cancer drug delivery, Polymer Chemistry 2018, 9, 438-449.

23. H. Zhang*, Y. Zhu*, Y. Shen*, Microfluidics for cancer nanomedicine: From fabrication to evaluation, Small 2018, e1800360-e1800360.

24. H. Zhang, C. Fu, Y. Yi, X. Zhou, C. Zhou, G. Ying, Y. Shen*, Y. Zhu*, A magnetic-based SERS approach for highly sensitive and reproducible detection of cancer-related serum microRNAs, Analytical Methods, 2018, 10, 624-633.

25. W. Yu, M. Ye, J. Zhu, Y. Wang, C. Liang, J. Tang, H. Tao, Y. Shen, Zinc phthalocyanine encapsulated in polymer micelles as a potent photosensitizer for the photodynamic therapy of osteosarcoma, Nanomedicine: Nanotechnology, Biology, and Medicine, 14 (2018) 1099-1110.

26. F. Xu, H. Zhong, Y. Chang, D. Li, H. Jin, M. Zhang, H. Wang, C. Jiang, Y. Shen, Y. Huang, Targeting death receptors for drug-resistant cancer therapy: Codelivery of pTRAIL and monensin using dual-targeting and stimuli-responsive self-assembling nanocomposites, Biomaterials 2018, 158, 56-73.

27. J. Xiang, B. Wu, ZX. Zhou*, S. Hu, Y. Piao, Q. Zhou, G. Wang, J. Tang, X. Liu, Y. Shen*, Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy, Science China-Life Sciences 2018, 61, 436-447.

28. Z. Zhang, Y.C. Zhou, Z.X. Zhou*, Y. Piao, K. Kalva, X.R. Liu, J.B. Tang, Y. Shen*, Synthesis of enzyme-responsive phosphoramidate dendrimers for cancer drug delivery. Polymer Chemistry 2018, 9, 438-449.

29. S.Q. Shao. Q. Zhou, J.X. Si, J. Tang, X. Liu, M. Wang, J. Gao, K. Wang, R. Xu, and Y. Shen*, A noncytotoxic dendrimer of innate and potent anticancer and anti-metastatic activities, Nature Biomedical Engineering, 2017, 1, 745–757.

30. Z. Zhou, X. Liu, D. Zhu, Y. Wang, Z. Zhang, X. Zhou, N. Qiu, X. Chen, Y. Shen*, Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration, Advanced Drug Delivery Reviews, 2017, 115, 115-154.

31. M. Ye, Y. Han, J. Tang*, Y. Piao, X. Liu, Z. Zhou, J. Gao*, J. Rao, Y. Shen, A tumor-specific cascade amplification drug release nanoparticle for overcoming multidrug resistance in cancers,  Advanced Materials (2017), Ahead of Print, online.

32. Q. Sun, Z. Zhou, N. Qiu and Y. Shen*, Rational design of cancer nanomedicine: nanoproperty integration and synchronization, Advanced Materials 2017, 29, 1606628; DOI: 10.1002/adma.201606628

33. D. Zhu, H. Yan, X. Liu, J. Xiang, Z. Zhou, J. Tang, X. Liu and Y. Shen*, Intracellularly disintegratable polysulfoniums for efficient gene delivery, Advanced Functional Materials 2017, 27, 1606826. DOI: 10.1002/adfm.201606826

34. X. Liu, J. Xiang, D. Zhu, L. Jiang, Z. Zhou, J. Tang, X. Liu, Y. Huang and Y. Shen*, Fusogenic reactive oxygen species triggered charge-reversal vector for effective gene delivery, Advanced Materials  2016, 28, 1743-1752.

35. N. Qiu, X. Liu, Y. Zhong, Z. Zhou, Y. Piao, L. Miao, Q. Zhang, J. Tang, L. Huang and Y. Shen*, Esterase-activated charge-reversal polymer for fibroblast-exempt cancer gene therapy, Advanced Materials 2016, 28, 10613-10622..

36. J. Si, S. Shao, Y. Shen* and K. Wang*, Macrophages as active nanocarriers for targeted early and adjuvant cancer chemotherapy, Small  2016, 12, pp. 5108-5119.

37. Q. Sun, X. Ma, B. Zhang, Z. Zhou, E. Jin, Y. Shen*, E.A. Van Kirk, W.J. Murdoch, M. Radosz and W. Sun, Fabrication of dendrimer-releasing lipidic nanoassembly for cancer drug delivery, Biomaterials Science  2016, 4, 958-969.

38. X. Xi, S. Hu, Z. Zhou*, X. Liu, J. Tang and Y. Shen*, Dendrimers with the protocatechuic acid building block for anticancer drug delivery, Journal of Materials Chemistry B  2016, 4, 5236-5245.

39. C.-h. Xu, Q. Zhou, D.-c. Zhu, N.-s. Qiu, S.-q. Shao, X.-r. Liu and Y. Shen*, Esterase-activated self-immolative polymeric vector based on menschutkin reaction for gene delivery, Acta Polymerica Sinica 2017, 937-945.

40. Y.-c. Zhou, Z.-x. Zhou and Y. Shen*, Facile synthesis of poly(hydroxypropylene imine) dendrimer from a single monomer, Acta Polymerica Sinica 2017, 359-366.

41. Z. Zhou, W.J. Murdoch and Y. Shen*, Synthesis of an esterase-sensitive degradable polyester as facile drug carrier for cancer therapy, Journal of Polymer Science Part A-Polymer Chemistry 2016, 54, 507-515.

42. L.-M. Li, M. Han, X.-C. Jiang, X.-Z. Yin, F. Chen, T.-Y. Zhang, H. Ren, J.-W. Zhang, T.-J. Hou, Z. Chen, H.-W. Ou-Yang, Y. Tabata, Y. Shen and J.-Q. Gao*, Peptide-tethered hydrogel scaffold promotes recovery from spinal cord transection via synergism with mesenchymal stem cells, Acs Applied Materials & Interfaces  2017,  9, 3330-3342.

43. Y. Li, H. Wang, K. Wang, Q. Hu, Q. Yao, Y. Shen, G. Yu and G. Tang*, Targeted co-delivery of ptx and tr3 sirna by ptp peptide modified dendrimer for the treatment of pancreatic cancer, Small 2017, 13, 1602697.

44. X. Liu, Q. Huang, C. Yang, Q. Zhang, W. Chen, Y. Shen and M. Sui*, A multi-stimuli responsive nanoparticulate SN38 prodrug for cancer chemotherapy, Journal of Materials Chemistry B  2017, 5, 661-670.

45. B. Pelaz, C. Alexiou, R.A. Alvarez -Puebla, F. Alves, A.M. Andrews, S. Ashraf, L.P. Balogh, L. Ballerini, A. Bestetti, C. Brendel, S. Bosi, M. Carril, W.C.W. Chan, C. Chen, X. Chen, X. Chen, Z. Cheng, D. Cui, J. Du, C. Dullin, A. Escudero, N. Feliu, M. Gao, M. George, Y. Gogotsi, A. Grunweller, Z. Gu, N.J. Halas, N. Hampp, R.K. Hartmann, M.C. Hersam, P. Hunziker, J. Jian, X. Jiang, P. Jungebluth, P. Kadhiresan, K. Kataoka, A. Khademhosseini, J. Kopecek, N.A. Kotov, H.F. Krug, D.S. Lee, C.-M. Lehr, K.W. Leong, X.-J. Liang, M.L. Lim, L.M. Liz-Marzan, X. Ma, P. Macchiarini, H. Meng, H. Mohwald, P. Mulvaney, A.E. Nel, S. Nie, P. Nordlander, T. Okano, J. Oliveira, T.H. Park, R.M. Penner, M. Prato, V. Puntes, V.M. Rotello, A. Samarakoon, R.E. Schaak, Y. Shen, et. al, Diverse applications of nanomedicine, Acs Nano 2017, 11,  2313-2381.

46. J. Tan, H. Wang, F. Xu, Y. Chen, M. Zhang, H. Peng, X. Sun, Y. Shen and Y. Huang*, Poly-gamma-glutamic acid-based ggt-targeting and surface camouflage strategy for improving cervical cancer gene therapy, Journal of Materials Chemistry B  2017,  5, 1315-1327.

47. H. Wang, Y. Li, M. Zhang, D. Wu, Y. Shen, G. Tang and Y. Ping*, Redox-activatable atp-depleting micelles with dual modulation characteristics for multidrug-resistant cancer therapy, Advanced Healthcare Materials  2017, 6, 1601293. DOI: 10.1002/adhm.201601293

48. Y. Han, Y. Qian, X. Zhou, H. Hu, X. Liu, Z. Zhou, J. Tang* and Y. Shen, Facile synthesis of zwitterionic polyglycerol dendrimers with a beta-cyclodextrin core as MRI contrast agent carriers, Polymer Chemistry  2016, 7, 6354-6362.

49. H. Hu, Y. Sheng, M. Ye, Y. Qian, J. Tang* and Y. Shen, A porphyrin-based magnetic and fluorescent dual-modal nanoprobe for tumor imaging, Polymer 2016, 88, 94-101.

50. X. Liu, M. Wu, Q. Hu, H. Bai, S. Zhang, Y. Shen, G. Tang* and Y. Ping*, Redox-activated light-up nanomicelle for precise imaging-guided cancer therapy and real-time pharmacokinetic monitoring, Acs Nano 2016, 10, 11385-11396.

51. Y. Lu, L. Miao, Y. Wang, Z. Xu, Y. Zhao, Y. Shen, G. Xiang and L. Huang*, Curcumin micelles remodel tumor microenvironment and enhance vaccine activity in an advanced melanoma model, Molecular Therapy 2016, 24, 364-374.

52. X. Mao, J. Si, Q. Huang, X. Sun, Q. Zhang, Y. Shen, J. Tang, X. Liu and M. Sui*, Self-assembling doxorubicin prodrug forming nanoparticles and effectively reversing drug resistance in vitro and in vivo, Advanced Healthcare Materials 2016, 5, 2517-2527.

53. M. Ye, X. Wang, J. Tang*, Z. Guo, Y. Shen, H. Tian and W.-H. Zhu*, Dual-channel nir activatable theranostic prodrug for in vivo spatiotemporal tracking thiol-triggered chemotherapy, Chemical Science  2016, 7, 4958-4965.

54. B.-w. Zhao, Z. Zhou and Y. Shen*, Effects of chirality on gene delivery efficiency of polylysine, Chinese Journal of Polymer Science 2016, 34, pp. 94-103.

55. X. Zhou, X. Liu, B. Zhao, X. Liu*, D. Zhu, N. Qiu, Q. Zhou, Y. Piao, Z. Zhou, J. Tang and Y. Shen, Jumping the nuclear envelop barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDKI inhibitor RO-3306, Journal of Controlled Release 2016, 234, 90-97.

56. Z. Chen, L. Zhang*, Y. He, Y. Shen and Y. Li, Enhanced shRNA delivery and ABCG2 silencing by charge-reversible layered nanocarriers, Small 2015, 11, 952-962.

57. S. Hu, E. Lee, C. Wang, J. Wang, Z. Zhou, Y. Li, X. Li, J. Tang, D.H. Lee, X. Liu and Y. Shen*, Amphiphilic drugs as surfactants to fabricate excipient-free stable nanodispersions of hydrophobic drugs for cancer chemotherapy, Journal of Controlled Release 2015, 220, 175-179.

58. Y. Shen*, Elastin-like polypeptide fusion for precision design of protein-polymer conjugates with improved pharmacology, Science China-Materials 2015, 58, 767-768.

59. J. Wang, W. Mao, L.L. Lock, J. Tang*, M. Sui, W. Sun, H. Cui, D. Xu and Y. Shen, The role of micelle size in tumor accumulation, penetration, and treatment, Acs Nano 2015, 9, 7195-7206.

60. T.-Y. Zhang, B. Huang, H.-B. Wu, J.-H. Wu, L.-M. Li, Y.-X. Li, Y.-L. Hu, M. Han, Y. Shen, Y. Tabata and J.-Q. Gao*, Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice, Journal of Controlled Release 2015, 209, 260-271.

61. Z. Zhou, W.J. Murdoch and Y. Shen*, A linear polyethylenimine (LPEI) drug conjugate with reversible charge to overcome multidrug resistance in cancer cells, Polymer 2015, 76, 150-158.

62. Z. Zhou, J. Tang, Q. Sun, W.J. Murdoch and Y. Shen*, A multifunctional PEG-PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery, Journal of Materials Chemistry B  2015, 3, 7594-7603.

63. M. Cao, X. Liu, T. Tang, M. Sui and Y. Shen*, Facile synthesis of size-tunable stable nanoparticles via click reaction for cancer drug delivery, Science China-Chemistry 2014, 57, 633-644.

64. Y. He, Y. Nie, G. Cheng, L. Xie, Y. Shen and Z. Gu*, Viral mimicking ternary polyplexes: a reduction-controlled hierarchical unpacking vector for gene delivery, Advanced Materials 2014, 26, 1534-1540.

65. K. Luo, B. He, Y. Wu, Y. Shen and Z. Gu*, Functional and biodegradable dendritic macromolecules with controlled architectures as nontoxic and efficient nanoscale gene vectors, Biotechnology Advances 2014, 32, 818-830.

66. U. Maddalena, A. Trachsel, P. Fankhauser, D.L. Berthier, D. Benczedi, W. Wang, X. Xi, Y. Shen and A. Herrmann*, Thioether profragrances: parameters influencing the performance of precursor-based fragrance delivery in functional perfumery, Chemistry & Biodiversity  2014, 11, 1700-1733.

67. L.-H. Peng, J. Niu, C.-Z. Zhang, W. Yu, J.-H. Wu, Y.-H. Shan, X.-R. Wang, Y. Shen, Z.-W. Mao, W.-Q. Liang and J.-Q. Gao*, TAT conjugated cationic noble metal nanoparticles for gene delivery to epidermal stem cells, Biomaterials 2014, 35, pp. 5605-5618.

68. G.-X. Ruan, Y.-Z. Chen, X.-L. Yao, A. Du, G.-P. Tang, Y.-Q. Shen, Y. Tabata and J.-Q. Gao*, Macrophage mannose receptor-specific gene delivery vehicle for macrophage engineering, Acta Biomaterialia 2014, 10, pp. 1847-1855.

69. G.-X. Ruan, T.-Y. Zhang, L.-M. Li, X.-G. Zhang, Y.-Q. Shen, Y. Tabata and J.-Q. Gao*, Hepatic-targeted gene delivery using cationic mannan vehicle, Molecular Pharmaceutics 2014, 11, 3322-3329.

70. S. Shao, J. Si, J. Tang, M. Sui and Y. Shen*, Jellyfish-shaped amphiphilic dendrimers: synthesis and formation of extremely uniform aggregates, Macromolecules 2014, 47, 916-921.

71. Q. Sun, X. Sun, X. Ma, Z. Zhou, E. Jin, B. Zhang, Y. Shen*, E.A. Van Kirk, W.J. Murdoch, J.R. Lott, T.P. Lodge, M. Radosz and Y.L. Zhao*, Integration of nanoassembly functions for an effective delivery cascade for cancer drugs, Advanced Materials 2014, 26, 7615-7621.

72. X.-J. Tang, M. Han, B. Yang, Y. Shen, Z.-G. He, D.-H. Xu and J.-Q. Gao*, Nanocarrier improves the bioavailability, stability and antitumor activity of camptothecin, International Journal of Pharmaceutics 2014, 477, 536-545.

73. X. Wu, X. Sun, Z. Guo, J. Tang*, Y. Shen, T.D. James, H. Tian and W. Zhu*, In Vivo and in situ tracking cancer chemotherapy by highly photostable nir fluorescent theranostic prodrug, Journal of the American Chemical Society 2014, 136, 3579-3588.

74. Z.X. Zhou, X.P. Ma, C.J. Murphy, E.L Jin, Q.H. Sun, Y. Shen*, E.A. Van Kirk, W.J. Murdoch: Molecularly precise dendrimer-drug conjugates with tunable drug release for cancer therapy. Angewandte Chemie-International Edition 2014, 53(41), 10949-10955.

75. J.Q. Wang, X.R. Sun, W.W. Mao, J.B. Tang, M.H. Sui, Y. Shen*, ZW Gu*: Prodrug nanocapsules responsive to tumor redox heterogeneity for cancer chemotherapy. Advanced Materials, 2013, 25(27), 3670-3676

76. E.L. Jin, B. Zhang, X.R. Sun, Z.X. Zhou, X.P. Ma, Q.H. Sun, J.B. Tang, Y. Shen*, EA Van Kirk, WJ Murdoch, M Radosz, Acid active cell-penetrating peptides for in vivo tumor-targeted drug delivery. Journal of the American Chemical Society  2013 Jan 16;135(2):933-40.

77. Z.X. Zhou, X.P. Ma, E.L. Jin, .JB. Tang, M.H. Sui, Y. Shen*, EA Van Kirk, WJ Murdoch, M Radosz. Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery. Biomaterials 2013, 34(22):5722-35.

78. M.Z. Ye, Y. Qian, J.B. Tang, H.J. Hu, M.H. Sui, Y. Shen. Targeted biodegradable dendritic MRI contrast agent for enhanced tumor imaging. Journal Controlled Release 2013, 169(3):239-45.

79. H.F. Zhang, J.Q. Wang, W.W. Mao, J. Huang, X.G. Wu, Y. Shen, M.H. Sui*, Novel SN38 conjugate-forming nanoparticles as anticancer prodrug: In vitro and in vivo studies, Journal of Controlled Release 2013 Mar 10;166(2):147-58..

80. B. Zhang, X.P. Ma, W.J. Murdoch, M. Radosz, Y. Shen*: Bioreducible poly(amido amine)s with different branching degrees as gene delivery vectors. Biotechnology and Bioengineering 2013, 110(3):990-8..

81. J.B. Tang, Y.Q. Sheng, H.J. Hu, Y. Shen*: Macromolecular MRI contrast agents: structures, properties and applications. Progress in Polymer Science  2013, 38(3–4), 462–502.

82. X.P. Ma, J.B. Tang, Z.X. Zhou, E.L. Jin, Q.H. Sun, B. Zhang, Y. Shen *, Facile synthesis of polyester dendrimers as drug delivery carriers. Macromolecules 2013, 46 (1),  37–42.

83. P.F. Gou,  W.W. Liu, W.W. Mao,  J.B. Tang,  Y. Shen and MH Sui* Self-assembling doxorubicin prodrug forming nanoparticles for cancer chemotherapy: synthesis and anticancer study in vitro and in vivo, Journal of Materials Chemistry B, 2013, 1, 284-292.

84. X.P. Ma, Q.H. Sun, Z.X. Zhou, E.L. Jin, J.B. Tang, E.V. Kirk, W.J. Murdoch and Y. Shen*, Synthesis of degradable bifunctional dendritic polymers as versatile drug carriers, Polymer Chemistry 2013, 4:812-819.

85. Q.H. Sun, M. Radosz, Y. Shen *, Challenges in design of translational nanocarriers, Journal of Controlled Release  2012, 164(2) 156-169.

86. M.H. Sui, H.F. Zhang, X. Di, J. Chang, Y. Shen, W.M. Fan*, G2 checkpoint abrogator abates the antagonistic interaction between antimicrotubule drugs and radiation therapy Radiotherapy and Oncology  2012, 104(2), 243-248.

87. M.Z. Ye, Y. Qian, Y. Shen, H.J. Hu, M.H. Sui, JB Tang*, Facile synthesis and in vivo evaluation of biodegradable dendritic MRI contrast agents. Journal of Materials Chemistry 2012, 22(29):14369-14377.

88. J. Yang, X.R. Sun, W.W. Mao, M.H. Sui, J.B. Tang*, Y. Shen*: Conjugate of Pt(IV)-histone deacetylase inhibitor as a prodrug for cancer chemotherapy. Molecular Pharmaceutics  2012, 9(10):2793-2800.

89. Z. Tyrrell, Y. Shen*, M. Radosz*: Multilayered nanoparticles for controlled release of paclitaxel formed by near-critical micellization of triblock copolymers. Macromolecules 2012, 45(11):4809-4817.

90. K.D. Lu, M.Z. Cao, W.W. Mao, X.R. Sun, J.B. Tang, Y. Shen*, M. Sui*: Targeted acid-labile conjugates of norcantharidin for cancer chemotherapy. Journal of Materials Chemistry   2012, 22(31):15804-15811.

91. Z.X. Zhou, Y. Shen*, J.B. Tang, E.L. Jin, X.P. Ma, Q.H. Sun, B. Zhang, E.A. Van Kirk, W.J. Murdoch, Linear polyethyleneimine-based charge-reversal nanoparticles for nuclear-targeted drug delivery. Journal of Materials Chemistry 2011, 21(47):19114-19123.

92. J. Yang, W.W. Liu, M.H. Sui*, J.B. Tang, Y. Shen*, Platinum (IV)-coordinate polymers as intracellular reduction-responsive backbone-type conjugates for cancer drug delivery. Biomaterials 2011, 32(34):9136-9143.

93. Z. Tyrrell, Y. Shen*, M. Radosz*, Near-critical fluid micellization for high and efficient drug loading: Encapsulation of paclitaxel into PEG-b-PCL micelles. Journal of Physical Chemistry C 2011, 115(24):11951-11956.

94. M.H. Sui, W.W. Liu, Y. Shen*, Nuclear drug delivery for cancer chemotherapy. Journal of Controlled Release  2011, 155(2): 227-236.

95. Y. Shen*, X.P. Ma, B. Zhang, Z.X.Zhou, Q.H. Sun, E.L. Jin, M.H. Sui, J.B. Tang, J.Q. Wang, M.H. Fan, Degradable dual pH- and temperature-responsive photoluminescent dendrimers. Chemistry-A European Journal 2011, 17(19): 5319-5326.

96. Z.C. Chen, J.B. Tang, Y. Shen*, X.P. Wang*, Click synthesis of topological macromolecules, Science China 2011, 41(2): 281-303.

97. H.D. Tang, C. Murphy, B. Zhang, Y. Shen*, EA Van Kirk, W J Murdoch, Curcumin polymers for cancer drug delivery, Biomaterials   2010, 31(27): 7139-7149.

98. Y. Shen*, Z.X. Zhou, P.S. Xu, E.A. Van kirk, W. J. Murdoch, Charge-reversal PAMAM dendrimer for nuclear drug delivery, Nanomedicine (UK)  2010, 5(8): 1205-1217.

    
    

授权专利：

1. 申有青等，PCT世界专利：含硫脲树枝状大分子和含硫脲超支化聚合物及其制备方法和应用，PCT/CN2015/07/1874 (正在进入美国专利)

2. 申有青、唐建斌等，中国发明专利：一种聚酯树枝状大分子的制备方法，专利号：ZL200910100118.0，授权日： 2011.5.25

3. 申有青、唐建斌等，中国发明专利：喜树碱及其衍生物的自乳化药物前体及其应用，专利号：ZL200910102143.2，授权日： 2011.8.20 （成果已转让）

4. 申有青、胡诗琪等：利用双亲性药物包载疏水性抗肿瘤药物的方法及制剂，专利号: ZL 2013 1 0553279.1（成果已转让）

5.   Maciej Radosz, Youqing Shen, Huadong Tang, 美国发明专利，Highly active catalyst for atom transfer radical polymerization，专利号：US7994087B2，授权日：2011.8.9

6.   S. Zhu, Y. Shen, R. Pelton, Tertiary amine methacrylate-based macromonomers and polymers, US Patent number: 6630557, Issue date: 7 Oct 2003.

申请专利:

1. 申有青、唐建斌、隋梅花、王金强，自纳米化7－乙基－10－羟基喜树碱（SN38）的纳米抗癌药物的制备方法，中国专利申请：申请号：201010561727.9，申请日：2010.11.26；公开(公告)号： CN102060991A.

2. 申有青;唐建斌;苟鹏飞;隋梅花，一种自乳化阿霉素纳米药物及其制备方，中国专利申请：申请号：201110113954.X，申 请 日：2011.05.04 ，公开(公告)号：CN102188717A， 公开(公告)日：2011.09.21.  3.   Y. Shen, H. Tang, E. Van Kirk, W. J. Murdoch, M. Radosz,  Curcumin-containing polymers as prodrugs or prodrug carriers.  US Patent Application 20120003177, Kind Code A1, January 5, 2012; PCT NO:  PCT/US09/57303.

4.   Y. Shen, P. Xu, Charge reversible polymers. US Patent Application Number: 13/033,247; Publication number: US 2011/0244046 A1; Filing date: 23 Feb 2011.

5.   Y. Shen, H. Tang, M. Radosz, Amine-containing compounds for enhancing the activity of ATRP catalysts and removal of the terminal halogen groups from the ATRP polymer products. Application number: 11/958,336; Publication number: US 2009/0156771 A1; Filing date: 17 Dec 2007

6.   M. Radosz, Y. Shen, E. A. Van Kirk, W. J. Murdoch, Degradable polymeric nanogel for drug delivery. US patent Application number: 11/599,531; Publication number: US 2007/0224164 A1; Filing date: 14 Nov 2006

7.   M. Radosz, Y. Shen, Processing nanoparticles by micellization of blocky-copolymers in subcritical and supercritical solvents, US Patent Application 20100270695, Kind Code  A1, Appl. Date:  October 28, 2010; PCT NO:  PCT/US07/19370.

8.   M. Radosz and Y. Shen, Poly(ionic liquid)s as new materials for CO2 separation and other applications, US Patent Application 20090266230, Kind Code  A1, Appl. Date:  October 29, 2009; PCT NO:  PCT/US05/27833

9.   M. Radosz, Y. Shen, H. Tang, Polymers and copolymers of ionic liquids as radio frequency absorbing materials, US Patent Application 20080125559, Kind Code  A1, Appl Date:  May 29, 2008; PCT NO:  PCT/US05/40651.